Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice

Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice

Dyslipidemia is considered a risk factor for type 2 diabetes (T2D), yet studies with statins and candidate genes suggest that circulating lipids may protect against T2D development. <i>Apoe</i>-null (<i>Apoe<sup>-/-</sup></i>) mouse strains develop spontaneous dys...

Full description

Bibliographic Details
Main Authors:	Lisa J. Shi, Xiwei Tang, Jiang He, Weibin Shi
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	dyslipidemia type 2 diabetes quantitative trait locus low-density lipoprotein high fat diet
Online Access:	https://www.mdpi.com/1422-0067/23/11/6184

Similar Items

Phenotypic and Genetic Evidence for a More Prominent Role of Blood Glucose than Cholesterol in Atherosclerosis of Hyperlipidemic Mice
by: Ashley M. Abramson, et al.
Published: (2022-08-01)

Compendium of genome-wide scans of lipid-related phenotypes
by: Yohan Bossé, et al.
Published: (2004-12-01)

Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene[S]
by: Zhiguang Su, et al.
Published: (2009-10-01)

Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice
by: Lisa J. Shi, et al.
Published: (2022-03-01)

Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis
by: Cheryl Ackert-Bicknell, et al.
Published: (2013-04-01)

Detection of QTL for traits related to adaptation to sub-optimal climatic conditions in chickens
by: Ching-Yi Lien, et al.
Published: (2017-04-01)

Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques[S]
by: G.M. Anantharamaiah, et al.
Published: (2018-11-01)

Data on genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice
by: Andrew T. Grainger, et al.
Published: (2016-12-01)

Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses
by: Yoannah François, et al.
Published: (2017-04-01)

How realistic are the LDL-C targets in new dyslipidemia guidelines - is it possible to reach the targets?
by: Barış Güngör
Published: (2020-03-01)

Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice1
by: Vincent W. Bloks, et al.
Published: (2001-01-01)

Heritability and genetic loci of fatty liver in familial combined hyperlipidemia
by: Martijn C. G.J. Brouwers, et al.
Published: (2006-12-01)

<i>Ldlr</i>-Deficient Mice with an Atherosclerosis-Resistant Background Develop Severe Hyperglycemia and Type 2 Diabetes on a Western-Type Diet
by: Weibin Shi, et al.
Published: (2022-06-01)

Dietary advice to cardiovascular patients. A brief update for physicians
by: Francesco Visioli, et al.
Published: (2019-04-01)

Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study[S]
by: Ardashel Latsuzbaia, et al.
Published: (2016-12-01)

Lipid profile of healthy women during normal pregnancy
by: Diareme Margarita, et al.
Published: (2009-01-01)

Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India
by: Rayabarapu Pranavchand, et al.
Published: (2017-06-01)

Mapping quantitative trait loci affecting fatness and breast muscle weight in meat-type chicken lines divergently selected on abdominal fatness
by: Neau André, et al.
Published: (2006-01-01)

Detection of quantitative trait loci for growth and fatness in pigs
by: Gellin Joël, et al.
Published: (2001-05-01)

Treatment of Hyperlipidemia: Consensus and Controversies
by: Christoph H Saely, et al.
Published: (2017-01-01)

LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins
by: Juha Vakkilainen, et al.
Published: (2002-04-01)

Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia
by: Joan Carles Escolà-Gil, et al.
Published: (2000-08-01)

Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia
by: Gwang‐Hoon Lee, et al.
Published: (2023-06-01)

Relationship between Disorders of Lipid Profile and Features of Liver Cirrhosis- An Open Prospective and Comparative Analysis of Patients of Stavropol Territory in Russian Federation
by: Temirlan Ruslanovich Dudov, et al.
Published: (2022-06-01)

Role of Helicobacter pylori Infection on Diabetic and Lipid Profile in Pre-diabetic Patients
by: Akash Chaudhary, et al.
Published: (2021-03-01)

The Significance of Lipoproteins in the Development of Obesity
by: Alexander Blagov, et al.
Published: (2024-03-01)

The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern?
by: Chen Gurevitz, et al.
Published: (2022-01-01)

Serum Lipoprotein (a) as a Diagnostic Marker of Coronary Artery Disease: A Case-Control Study
by: M.M. Kavitha, et al.
Published: (2018-07-01)

Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention
by: Jeffrey E. Jones, et al.
Published: (2023-11-01)

Characterization of apoM in normal and genetically modified mice
by: Kirsten Faber, et al.
Published: (2004-07-01)

Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides
by: Yukihito Higashi
Published: (2023-05-01)

A Jordanian Multidisciplinary Consensus Statement on the Management of Dyslipidemia
by: Eyas Al Mousa, et al.
Published: (2023-06-01)

The tangled web of dyslipidemia and cancer: Is there any association?
by: Sina Neshat, et al.
Published: (2022-01-01)

Long-term prognostic value of LDL-C, HDL-C, lp(a) and TG levels on cardiovascular disease incidence, by body weight status, dietary habits and lipid-lowering treatment: the ATTICA epidemiological cohort study (2002–2012)
by: Michael Georgoulis, et al.
Published: (2022-12-01)

Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice
by: Genevieve Marcelin, et al.
Published: (2012-05-01)

Causal effects of genetically predicted type 2 diabetes mellitus on blood lipid profiles and concentration of particle-size-determined lipoprotein subclasses: A two-sample Mendelian randomization study
by: Ken Chen, et al.
Published: (2022-10-01)

Gender Difference in Statin Intervention on Blood Lipid Control among Patients with Coronary Heart Disease
by: Chun-Yen Chen, et al.
Published: (2013-06-01)

Lipoprotein apheresis to treat elevated lipoprotein (a)1
by: Elisa Waldmann, et al.
Published: (2016-10-01)

Adherence to Statin Therapy and Attainment of LDL Cholesterol Goal Among Patients with Type 2 Diabetes and Dyslipidemia
by: Alwhaibi M, et al.
Published: (2019-12-01)

Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
by: Alice H. Lichtenstein, et al.
Published: (2002-02-01)