Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy
Stimulation of the vagal nerve is an effective treatment option in patients with pharmacoresistant epilepsy. Objective: to analyze the efficacy and safety of the Vagal Nerve Stimulation (VNS) procedure in patients suffering from pharmacoresistant epilepsy. Materials and Methods: The study included 1...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-04-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/454 |
| _version_ | 1797879376395632640 |
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| author | I. G. Areshkina D. V. Dmitrenko N. A. Shnayder E. A. Narodova |
| author_facet | I. G. Areshkina D. V. Dmitrenko N. A. Shnayder E. A. Narodova |
| author_sort | I. G. Areshkina |
| collection | DOAJ |
| description | Stimulation of the vagal nerve is an effective treatment option in patients with pharmacoresistant epilepsy. Objective: to analyze the efficacy and safety of the Vagal Nerve Stimulation (VNS) procedure in patients suffering from pharmacoresistant epilepsy. Materials and Methods: The study included 13 patients with pharmacoresistant epilepsy, aged 5 to 38 years. Results: among these patients, 25% reported a decrease in the number of epileptic seizures within one-month time after the first session of VNS. The efficacy of the treatment improved with a prolonged use of the VNS-therapy. Despite the long duration of the current pharmacoresistant form of epilepsy in most patients, a decrease in the severity of epileptic seizures and post-seizure disorientation was noted. Side effects of VNS-therapy were recorded in 38.5% of patients; in those, a correction of VNS parameters was performed. This approach allowed us to maintain the effective VNS-therapy and correct the arising side effects. Conclusion: vagal stimulation is an effective non-pharmacological option in patients with pharmacoresistant therapy who have contraindications for surgical treatment. The VNS-therapy reduces the occurrence rate of epileptic seizures by >50% in 20-50% of patients. The VNS therapy has a good long-term efficacy in patients of any age. Stimulation of the vagal nerve is usually well tolerated. |
| first_indexed | 2024-04-10T02:47:46Z |
| format | Article |
| id | doaj.art-64bc810ac1ed4904b28a099d80e65d70 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:47:46Z |
| publishDate | 2019-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-64bc810ac1ed4904b28a099d80e65d702023-03-13T07:44:17ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882019-04-01111273610.17749/2077-8333.2019.11.1.27-36430Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsyI. G. Areshkina0D. V. Dmitrenko1N. A. Shnayder2E. A. Narodova3Voino-Yasenetskii Krasnoyarsk State Medical UniversityVoino-Yasenetskii Krasnoyarsk State Medical UniversityBechterev National Medical Research Center of Psychiatry and NeurologyVoino-Yasenetskii Krasnoyarsk State Medical UniversityStimulation of the vagal nerve is an effective treatment option in patients with pharmacoresistant epilepsy. Objective: to analyze the efficacy and safety of the Vagal Nerve Stimulation (VNS) procedure in patients suffering from pharmacoresistant epilepsy. Materials and Methods: The study included 13 patients with pharmacoresistant epilepsy, aged 5 to 38 years. Results: among these patients, 25% reported a decrease in the number of epileptic seizures within one-month time after the first session of VNS. The efficacy of the treatment improved with a prolonged use of the VNS-therapy. Despite the long duration of the current pharmacoresistant form of epilepsy in most patients, a decrease in the severity of epileptic seizures and post-seizure disorientation was noted. Side effects of VNS-therapy were recorded in 38.5% of patients; in those, a correction of VNS parameters was performed. This approach allowed us to maintain the effective VNS-therapy and correct the arising side effects. Conclusion: vagal stimulation is an effective non-pharmacological option in patients with pharmacoresistant therapy who have contraindications for surgical treatment. The VNS-therapy reduces the occurrence rate of epileptic seizures by >50% in 20-50% of patients. The VNS therapy has a good long-term efficacy in patients of any age. Stimulation of the vagal nerve is usually well tolerated.https://www.epilepsia.su/jour/article/view/454epilepsysurgery for epilepsypharmacological resistancevagal nerve stimulationvns-therapy |
| spellingShingle | I. G. Areshkina D. V. Dmitrenko N. A. Shnayder E. A. Narodova Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy Эпилепсия и пароксизмальные состояния epilepsy surgery for epilepsy pharmacological resistance vagal nerve stimulation vns-therapy |
| title | Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| title_full | Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| title_fullStr | Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| title_full_unstemmed | Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| title_short | Efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| title_sort | efficacy and safety of vagal nerve stimulation in patients with pharmacoresistant epilepsy |
| topic | epilepsy surgery for epilepsy pharmacological resistance vagal nerve stimulation vns-therapy |
| url | https://www.epilepsia.su/jour/article/view/454 |
| work_keys_str_mv | AT igareshkina efficacyandsafetyofvagalnervestimulationinpatientswithpharmacoresistantepilepsy AT dvdmitrenko efficacyandsafetyofvagalnervestimulationinpatientswithpharmacoresistantepilepsy AT nashnayder efficacyandsafetyofvagalnervestimulationinpatientswithpharmacoresistantepilepsy AT eanarodova efficacyandsafetyofvagalnervestimulationinpatientswithpharmacoresistantepilepsy |