Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model

Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model

Abstract Background In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence on angio- and osteogenesis of adenoviral-mediated delivery of VEGF...

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Bibliographic Details
Main Authors: Sunita Sharma, Dipak Sapkota, Ying Xue, Saroj Rajthala, Mohammed A. Yassin, Anna Finne-Wistrand, Kamal Mustafa
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Stem Cell Research & Therapy
Subjects:
Bone regeneration
Scaffold
Mesenchymal stem cell
BMP2 and VEGFA
Angiogenesis
Gene delivery
Online Access:http://link.springer.com/article/10.1186/s13287-018-0778-4

Internet

http://link.springer.com/article/10.1186/s13287-018-0778-4

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