Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility
AbstractBackground To distinguish the metabolic profile between women with diminished ovarian reserve (DOR) and those with normal ovarian reserve (NOR).Methods In this retrospective study, we enrolled 524 women under the age of 40 who were experiencing infertility: 261 in the DOR group and 263 in th...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2023.2282722 |
| _version_ | 1827632270080475136 |
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| author | Yuehong Lu Zhoulan Xia |
| author_facet | Yuehong Lu Zhoulan Xia |
| author_sort | Yuehong Lu |
| collection | DOAJ |
| description | AbstractBackground To distinguish the metabolic profile between women with diminished ovarian reserve (DOR) and those with normal ovarian reserve (NOR).Methods In this retrospective study, we enrolled 524 women under the age of 40 who were experiencing infertility: 261 in the DOR group and 263 in the NOR group. Physical characteristics and metabolic parameters were compared between these two groups.Results Women with DOR exhibited a higher propensity for elevated parameters including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), as well as heightened serum levels of homocysteine (Hcy), triglycerides (TG), low-density lipoprotein (LDL), and triglyceride-glucose (TyG) index, while concurrently experiencing reduced serum levels of high-density lipoprotein (HDL) (P < 0.05). Furthermore, the incidence rates of TG ≥ 1.7 mmol/L, hyperhomocysteinemia (HHcy), BMI ≥ 25 kg/m2, SBP/DBP ≥ 130/85 mmHg, and metabolic syndrome (MS) were significantly elevated within the DOR group as compared to the NOR group (P < 0.05).Conclusion The prevalence of metabolic disturbances and HHcy were notably elevated in women with infertility and DOR compared to those with NOR. |
| first_indexed | 2024-03-09T14:33:44Z |
| format | Article |
| id | doaj.art-64bf26c435b8473781eeddb497217928 |
| institution | Directory Open Access Journal |
| issn | 0144-3615 1364-6893 |
| language | English |
| last_indexed | 2024-03-09T14:33:44Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-64bf26c435b8473781eeddb4972179282023-11-27T17:13:13ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932023-12-0143210.1080/01443615.2023.2282722Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertilityYuehong Lu0Zhoulan Xia1Center for Reproductive Medicine of Shaoxing Women and Children’s Hospital, Shaoxing, ChinaCenter for Reproductive Medicine of Shaoxing Women and Children’s Hospital, Shaoxing, ChinaAbstractBackground To distinguish the metabolic profile between women with diminished ovarian reserve (DOR) and those with normal ovarian reserve (NOR).Methods In this retrospective study, we enrolled 524 women under the age of 40 who were experiencing infertility: 261 in the DOR group and 263 in the NOR group. Physical characteristics and metabolic parameters were compared between these two groups.Results Women with DOR exhibited a higher propensity for elevated parameters including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), as well as heightened serum levels of homocysteine (Hcy), triglycerides (TG), low-density lipoprotein (LDL), and triglyceride-glucose (TyG) index, while concurrently experiencing reduced serum levels of high-density lipoprotein (HDL) (P < 0.05). Furthermore, the incidence rates of TG ≥ 1.7 mmol/L, hyperhomocysteinemia (HHcy), BMI ≥ 25 kg/m2, SBP/DBP ≥ 130/85 mmHg, and metabolic syndrome (MS) were significantly elevated within the DOR group as compared to the NOR group (P < 0.05).Conclusion The prevalence of metabolic disturbances and HHcy were notably elevated in women with infertility and DOR compared to those with NOR.https://www.tandfonline.com/doi/10.1080/01443615.2023.2282722Cardiovascular riskdyslipidemiahyperhomocysteinemiametabolic disturbancesovarian reserve |
| spellingShingle | Yuehong Lu Zhoulan Xia Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility Journal of Obstetrics and Gynaecology Cardiovascular risk dyslipidemia hyperhomocysteinemia metabolic disturbances ovarian reserve |
| title | Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| title_full | Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| title_fullStr | Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| title_full_unstemmed | Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| title_short | Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| title_sort | diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility |
| topic | Cardiovascular risk dyslipidemia hyperhomocysteinemia metabolic disturbances ovarian reserve |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2023.2282722 |
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