Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid
Abstract Background To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth....
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-05-01
|
Series: | BMC Ophthalmology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12886-019-1108-z |
_version_ | 1811273186342338560 |
---|---|
author | Junwon Lee Hee Jung Kwon Min Kim Christopher Seungkyu Lee Sung Chul Lee |
author_facet | Junwon Lee Hee Jung Kwon Min Kim Christopher Seungkyu Lee Sung Chul Lee |
author_sort | Junwon Lee |
collection | DOAJ |
description | Abstract Background To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth. Methods Retrospective chart review of 19 patients, who were diagnosed with choroidal neovascularization (CNV)-free small pigmented choroidal lesions and treated with IVB and/or TTT, was performed. Results Complete resolution of SFF was achieved in two eyes (2/14; 14.3%) after IVB, and in three eyes (3/4; 75%) after TTT. Best corrected visual acuity was improved in two eyes (2/9; 22%) after IVB, and in three eyes (3/4; 75%) after TTT. Among five patients who underwent TTT after IVB, four patients (4/5; 80%) demonstrated additional advantage. All IVBs could not reduce tumor sizes. Rather, tumor growth was detected in seven out of 14 eyes (7/14; 50%) that underwent IVB. None of the patients who underwent TTT showed tumor growth. The lack of treatment response to IVB was suggestive of malignancy, as most small pigmented lesions that had no response to IVB showed tumor growth (86%, p = 0.010). Conclusion IVB was not effective in reducing tumor size and subfoveal fluid in small pigmented choroidal lesions. Therapeutic response to IVB can be used as an indicator between melanoma and nevus in small pigmented choroidal lesion. |
first_indexed | 2024-04-12T22:53:33Z |
format | Article |
id | doaj.art-64bfad03de8b4c02a59dd34a16f6526d |
institution | Directory Open Access Journal |
issn | 1471-2415 |
language | English |
last_indexed | 2024-04-12T22:53:33Z |
publishDate | 2019-05-01 |
publisher | BMC |
record_format | Article |
series | BMC Ophthalmology |
spelling | doaj.art-64bfad03de8b4c02a59dd34a16f6526d2022-12-22T03:13:16ZengBMCBMC Ophthalmology1471-24152019-05-011911810.1186/s12886-019-1108-zTreatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluidJunwon Lee0Hee Jung Kwon1Min Kim2Christopher Seungkyu Lee3Sung Chul Lee4Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, CHA Bundang Medical Center, CHA UniversityDepartment of Ophthalmology, Institute of Human Barrier Research, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Human Barrier Research, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of MedicineAbstract Background To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth. Methods Retrospective chart review of 19 patients, who were diagnosed with choroidal neovascularization (CNV)-free small pigmented choroidal lesions and treated with IVB and/or TTT, was performed. Results Complete resolution of SFF was achieved in two eyes (2/14; 14.3%) after IVB, and in three eyes (3/4; 75%) after TTT. Best corrected visual acuity was improved in two eyes (2/9; 22%) after IVB, and in three eyes (3/4; 75%) after TTT. Among five patients who underwent TTT after IVB, four patients (4/5; 80%) demonstrated additional advantage. All IVBs could not reduce tumor sizes. Rather, tumor growth was detected in seven out of 14 eyes (7/14; 50%) that underwent IVB. None of the patients who underwent TTT showed tumor growth. The lack of treatment response to IVB was suggestive of malignancy, as most small pigmented lesions that had no response to IVB showed tumor growth (86%, p = 0.010). Conclusion IVB was not effective in reducing tumor size and subfoveal fluid in small pigmented choroidal lesions. Therapeutic response to IVB can be used as an indicator between melanoma and nevus in small pigmented choroidal lesion.http://link.springer.com/article/10.1186/s12886-019-1108-zBevacizumabSubfoveal fluidSmall pigmented choroidal lesionTranspupillary thermotherapyMelanoma |
spellingShingle | Junwon Lee Hee Jung Kwon Min Kim Christopher Seungkyu Lee Sung Chul Lee Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid BMC Ophthalmology Bevacizumab Subfoveal fluid Small pigmented choroidal lesion Transpupillary thermotherapy Melanoma |
title | Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
title_full | Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
title_fullStr | Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
title_full_unstemmed | Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
title_short | Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
title_sort | treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid |
topic | Bevacizumab Subfoveal fluid Small pigmented choroidal lesion Transpupillary thermotherapy Melanoma |
url | http://link.springer.com/article/10.1186/s12886-019-1108-z |
work_keys_str_mv | AT junwonlee treatmentresponsetointravitrealbevacizumabinsmallpigmentedchoroidallesionswithsubretinalfluid AT heejungkwon treatmentresponsetointravitrealbevacizumabinsmallpigmentedchoroidallesionswithsubretinalfluid AT minkim treatmentresponsetointravitrealbevacizumabinsmallpigmentedchoroidallesionswithsubretinalfluid AT christopherseungkyulee treatmentresponsetointravitrealbevacizumabinsmallpigmentedchoroidallesionswithsubretinalfluid AT sungchullee treatmentresponsetointravitrealbevacizumabinsmallpigmentedchoroidallesionswithsubretinalfluid |