The genetics of interstitial lung diseases
Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if pr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2019-09-01
|
| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/28/153/190053.full |
| _version_ | 1818335418076102656 |
|---|---|
| author | Raphael Borie Pierre Le Guen Mada Ghanem Camille Taillé Clairelyne Dupin Philippe Dieudé Caroline Kannengiesser Bruno Crestani |
| author_facet | Raphael Borie Pierre Le Guen Mada Ghanem Camille Taillé Clairelyne Dupin Philippe Dieudé Caroline Kannengiesser Bruno Crestani |
| author_sort | Raphael Borie |
| collection | DOAJ |
| description | Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD. |
| first_indexed | 2024-12-13T14:23:06Z |
| format | Article |
| id | doaj.art-64c028a3a56a465c929ce9fc75750217 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-13T14:23:06Z |
| publishDate | 2019-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-64c028a3a56a465c929ce9fc757502172022-12-21T23:42:02ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172019-09-012815310.1183/16000617.0053-20190053-2019The genetics of interstitial lung diseasesRaphael Borie0Pierre Le Guen1Mada Ghanem2Camille Taillé3Clairelyne Dupin4Philippe Dieudé5Caroline Kannengiesser6Bruno Crestani7 Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France INSERM U1152, Paris, France INSERM U1152, Paris, France Service de Pneumologie A, Hôpital Bichat, AP-HP, Paris, France Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.http://err.ersjournals.com/content/28/153/190053.full |
| spellingShingle | Raphael Borie Pierre Le Guen Mada Ghanem Camille Taillé Clairelyne Dupin Philippe Dieudé Caroline Kannengiesser Bruno Crestani The genetics of interstitial lung diseases European Respiratory Review |
| title | The genetics of interstitial lung diseases |
| title_full | The genetics of interstitial lung diseases |
| title_fullStr | The genetics of interstitial lung diseases |
| title_full_unstemmed | The genetics of interstitial lung diseases |
| title_short | The genetics of interstitial lung diseases |
| title_sort | genetics of interstitial lung diseases |
| url | http://err.ersjournals.com/content/28/153/190053.full |
| work_keys_str_mv | AT raphaelborie thegeneticsofinterstitiallungdiseases AT pierreleguen thegeneticsofinterstitiallungdiseases AT madaghanem thegeneticsofinterstitiallungdiseases AT camilletaille thegeneticsofinterstitiallungdiseases AT clairelynedupin thegeneticsofinterstitiallungdiseases AT philippedieude thegeneticsofinterstitiallungdiseases AT carolinekannengiesser thegeneticsofinterstitiallungdiseases AT brunocrestani thegeneticsofinterstitiallungdiseases AT raphaelborie geneticsofinterstitiallungdiseases AT pierreleguen geneticsofinterstitiallungdiseases AT madaghanem geneticsofinterstitiallungdiseases AT camilletaille geneticsofinterstitiallungdiseases AT clairelynedupin geneticsofinterstitiallungdiseases AT philippedieude geneticsofinterstitiallungdiseases AT carolinekannengiesser geneticsofinterstitiallungdiseases AT brunocrestani geneticsofinterstitiallungdiseases |