Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients
There is still debate over how reviewing oncological histories and addressing appropriate therapies in multidisciplinary team (MDT) discussions may affect patients’ overall survival (OS). The aim of this study was to describe MDT outcomes for a single cancer center’s patients affected by colorectal...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/16/3952 |
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| author | Flavio Milana Simone Famularo Antonio Luberto Lorenza Rimassa Marta Scorsetti Tiziana Comito Tiziana Pressiani Ciro Franzese Dario Poretti Luca Di Tommaso Nicola Personeni Marcello Rodari Vittorio Pedicini Matteo Donadon Guido Torzilli |
| author_facet | Flavio Milana Simone Famularo Antonio Luberto Lorenza Rimassa Marta Scorsetti Tiziana Comito Tiziana Pressiani Ciro Franzese Dario Poretti Luca Di Tommaso Nicola Personeni Marcello Rodari Vittorio Pedicini Matteo Donadon Guido Torzilli |
| author_sort | Flavio Milana |
| collection | DOAJ |
| description | There is still debate over how reviewing oncological histories and addressing appropriate therapies in multidisciplinary team (MDT) discussions may affect patients’ overall survival (OS). The aim of this study was to describe MDT outcomes for a single cancer center’s patients affected by colorectal liver metastases (CRLMs). From 2010 to 2020, a total of 847 patients with CRLMs were discussed at our weekly MDT meeting. Patients’ characteristics and MDT decisions were analyzed in two groups: patients receiving systemic therapy (ST) versus patients receiving locoregional treatment (LRT). Propensity-score matching (PSM) was run to reduce the risk of selection bias. The median time from MDT indication to treatment was 27 (IQR 13–51) days. The median OS was 30 (95%CI = 27–34) months. After PSM, OS for patients undergoing LRT was 51 (95%CI = 36–64) months compared with 15 (95%CI = 13–20) months for ST patients (<i>p</i> < 0.0001). In this large retrospective study, the MDT discussions were useful in providing the patients with all available locoregional options. |
| first_indexed | 2024-03-09T13:43:13Z |
| format | Article |
| id | doaj.art-64c26f68ed0d4f90996f32fef989519e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:43:13Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-64c26f68ed0d4f90996f32fef989519e2023-11-30T21:04:23ZengMDPI AGCancers2072-66942022-08-011416395210.3390/cancers14163952Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 PatientsFlavio Milana0Simone Famularo1Antonio Luberto2Lorenza Rimassa3Marta Scorsetti4Tiziana Comito5Tiziana Pressiani6Ciro Franzese7Dario Poretti8Luca Di Tommaso9Nicola Personeni10Marcello Rodari11Vittorio Pedicini12Matteo Donadon13Guido Torzilli14Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyHumanitas Cancer Center, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Radiology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Nuclear Medicine, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Radiology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyThere is still debate over how reviewing oncological histories and addressing appropriate therapies in multidisciplinary team (MDT) discussions may affect patients’ overall survival (OS). The aim of this study was to describe MDT outcomes for a single cancer center’s patients affected by colorectal liver metastases (CRLMs). From 2010 to 2020, a total of 847 patients with CRLMs were discussed at our weekly MDT meeting. Patients’ characteristics and MDT decisions were analyzed in two groups: patients receiving systemic therapy (ST) versus patients receiving locoregional treatment (LRT). Propensity-score matching (PSM) was run to reduce the risk of selection bias. The median time from MDT indication to treatment was 27 (IQR 13–51) days. The median OS was 30 (95%CI = 27–34) months. After PSM, OS for patients undergoing LRT was 51 (95%CI = 36–64) months compared with 15 (95%CI = 13–20) months for ST patients (<i>p</i> < 0.0001). In this large retrospective study, the MDT discussions were useful in providing the patients with all available locoregional options.https://www.mdpi.com/2072-6694/14/16/3952multidisciplinary team meetingcolorectal cancercolorectal liver metastases |
| spellingShingle | Flavio Milana Simone Famularo Antonio Luberto Lorenza Rimassa Marta Scorsetti Tiziana Comito Tiziana Pressiani Ciro Franzese Dario Poretti Luca Di Tommaso Nicola Personeni Marcello Rodari Vittorio Pedicini Matteo Donadon Guido Torzilli Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients Cancers multidisciplinary team meeting colorectal cancer colorectal liver metastases |
| title | Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients |
| title_full | Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients |
| title_fullStr | Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients |
| title_full_unstemmed | Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients |
| title_short | Multidisciplinary Tumor Board in the Management of Patients with Colorectal Liver Metastases: A Single-Center Review of 847 Patients |
| title_sort | multidisciplinary tumor board in the management of patients with colorectal liver metastases a single center review of 847 patients |
| topic | multidisciplinary team meeting colorectal cancer colorectal liver metastases |
| url | https://www.mdpi.com/2072-6694/14/16/3952 |
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