Effects of triclabendazole and its metabolite exposure on the heart‐rate–corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individuals

Abstract Triclabendazole is an effective and well‐tolerated treatment for human fascioliasis. A placebo‐ and positive‐controlled, four‐sequence by four‐period crossover study was conducted in 45 healthy participants to assess the effect of therapeutic (10 mg/kg twice daily [b.i.d.] for 1 day) and su...

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Bibliographic Details
Main Authors: William T. Prince, Vinay Kumar Venishetty, Jean Lecot, Kasra Shakeri‐Nejad, Cathy Gray, Amanda Taylor, Ganesh R. Iyer, Julia Zack
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13564