Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells
The inositol 1,4,5-trisphosphate receptor (IP3R) is one of two Ca2+ channels that gates Ca2+ release from ER-stores. The ligand IP3, generated upon specific G-protein coupled receptor activation, binds to IP3R to release Ca2+ into the cytosol. IP3R also mediates ER-store Ca2+ release into the mitoch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Fly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336934.2017.1384103 |
| _version_ | 1797678359835049984 |
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| author | Megha Gaiti Hasan |
| author_facet | Megha Gaiti Hasan |
| author_sort | Megha |
| collection | DOAJ |
| description | The inositol 1,4,5-trisphosphate receptor (IP3R) is one of two Ca2+ channels that gates Ca2+ release from ER-stores. The ligand IP3, generated upon specific G-protein coupled receptor activation, binds to IP3R to release Ca2+ into the cytosol. IP3R also mediates ER-store Ca2+ release into the mitochondria, under basal as well as stimulatory conditions; an activity that influences cellular bioenergetics and thus, cellular growth and proliferation. In Drosophila neuroendocrine cells expressing a hypomorphic mutant of IP3R, we observed reduced protein translation levels. Here, we discuss the possible molecular mechanism for this observation. We hypothesize that the cellular energy sensor, AMPK connects IP3R mediated Ca2+ release into the mitochondria, to protein translation, via the TOR pathway. |
| first_indexed | 2024-03-11T22:58:35Z |
| format | Article |
| id | doaj.art-64c5a352ecbc4e308191b603f8fa39d9 |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:35Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-64c5a352ecbc4e308191b603f8fa39d92023-09-21T15:09:08ZengTaylor & Francis GroupFly1933-69341933-69422017-10-0111429029610.1080/19336934.2017.13841031384103Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cellsMegha0Gaiti Hasan1National Centre for Biological Sciences-TIFR, GKVK CampusNational Centre for Biological Sciences-TIFR, GKVK CampusThe inositol 1,4,5-trisphosphate receptor (IP3R) is one of two Ca2+ channels that gates Ca2+ release from ER-stores. The ligand IP3, generated upon specific G-protein coupled receptor activation, binds to IP3R to release Ca2+ into the cytosol. IP3R also mediates ER-store Ca2+ release into the mitochondria, under basal as well as stimulatory conditions; an activity that influences cellular bioenergetics and thus, cellular growth and proliferation. In Drosophila neuroendocrine cells expressing a hypomorphic mutant of IP3R, we observed reduced protein translation levels. Here, we discuss the possible molecular mechanism for this observation. We hypothesize that the cellular energy sensor, AMPK connects IP3R mediated Ca2+ release into the mitochondria, to protein translation, via the TOR pathway.http://dx.doi.org/10.1080/19336934.2017.1384103ampklarvaestarvationtor |
| spellingShingle | Megha Gaiti Hasan Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells Fly ampk larvae starvation tor |
| title | Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells |
| title_full | Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells |
| title_fullStr | Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells |
| title_full_unstemmed | Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells |
| title_short | Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells |
| title_sort | control of protein translation by ip3r mediated ca2 release in drosophila neuroendocrine cells |
| topic | ampk larvae starvation tor |
| url | http://dx.doi.org/10.1080/19336934.2017.1384103 |
| work_keys_str_mv | AT megha controlofproteintranslationbyip3rmediatedca2releaseindrosophilaneuroendocrinecells AT gaitihasan controlofproteintranslationbyip3rmediatedca2releaseindrosophilaneuroendocrinecells |