Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches
In the present study, the preparation of controlled-released leflunomide (LFD)-loaded skin patches was evaluated, utilizing the combination of chitosan (CS) nanoparticles (NPs) incorporated into suitable poly(l-lactic acid) (PLLA) or poly(lactic-<i>co</i>-glycolic acid) (PLGA) polyester...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/10/1539 |
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| author | Stavroula G. Nanaki Sophia Andrianidou Panagiotis Barmpalexis Evi Christodoulou Dimitrios N. Bikiaris |
| author_facet | Stavroula G. Nanaki Sophia Andrianidou Panagiotis Barmpalexis Evi Christodoulou Dimitrios N. Bikiaris |
| author_sort | Stavroula G. Nanaki |
| collection | DOAJ |
| description | In the present study, the preparation of controlled-released leflunomide (LFD)-loaded skin patches was evaluated, utilizing the combination of chitosan (CS) nanoparticles (NPs) incorporated into suitable poly(l-lactic acid) (PLLA) or poly(lactic-<i>co</i>-glycolic acid) (PLGA) polyester matrices. Initially, LFD-loaded CS NPs of ~600 nm and a smooth surface were prepared, while strong inter-molecular interactions between the drug and the CS were unraveled. In the following step, the prepared LFD-loaded CS NPs were incorporated into PLLA or PLGA, and thin-film patches were prepared via spin-coating. Analysis of the prepared films showed that the incorporation of the drug-loaded CS NPs resulted in a significant increase in the drug’s release rate and extent as compared to neat LFD-loaded polyester patches (i.e., prepared without the use of CS NPs). In-depth analysis of the prepared formulations showed that the amorphization of the drug within the matrix and the increased wetting properties of the prepared CS NPs were responsible for the improved thin-film patch characteristics. |
| first_indexed | 2024-03-10T11:31:41Z |
| format | Article |
| id | doaj.art-64c60c0ba2bf4c3ba67894afaefcd942 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T11:31:41Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-64c60c0ba2bf4c3ba67894afaefcd9422023-11-21T19:13:46ZengMDPI AGPolymers2073-43602021-05-011310153910.3390/polym13101539Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin PatchesStavroula G. Nanaki0Sophia Andrianidou1Panagiotis Barmpalexis2Evi Christodoulou3Dimitrios N. Bikiaris4Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceIn the present study, the preparation of controlled-released leflunomide (LFD)-loaded skin patches was evaluated, utilizing the combination of chitosan (CS) nanoparticles (NPs) incorporated into suitable poly(l-lactic acid) (PLLA) or poly(lactic-<i>co</i>-glycolic acid) (PLGA) polyester matrices. Initially, LFD-loaded CS NPs of ~600 nm and a smooth surface were prepared, while strong inter-molecular interactions between the drug and the CS were unraveled. In the following step, the prepared LFD-loaded CS NPs were incorporated into PLLA or PLGA, and thin-film patches were prepared via spin-coating. Analysis of the prepared films showed that the incorporation of the drug-loaded CS NPs resulted in a significant increase in the drug’s release rate and extent as compared to neat LFD-loaded polyester patches (i.e., prepared without the use of CS NPs). In-depth analysis of the prepared formulations showed that the amorphization of the drug within the matrix and the increased wetting properties of the prepared CS NPs were responsible for the improved thin-film patch characteristics.https://www.mdpi.com/2073-4360/13/10/1539leflunomidechitosanaliphatic polyesterspoly(l-lactic acid)poly(lactic co glycolic acid)nanoparticles |
| spellingShingle | Stavroula G. Nanaki Sophia Andrianidou Panagiotis Barmpalexis Evi Christodoulou Dimitrios N. Bikiaris Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches Polymers leflunomide chitosan aliphatic polyesters poly(l-lactic acid) poly(lactic co glycolic acid) nanoparticles |
| title | Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches |
| title_full | Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches |
| title_fullStr | Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches |
| title_full_unstemmed | Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches |
| title_short | Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches |
| title_sort | leflunomide loaded chitosan nanoparticles for the preparation of aliphatic polyester based skin patches |
| topic | leflunomide chitosan aliphatic polyesters poly(l-lactic acid) poly(lactic co glycolic acid) nanoparticles |
| url | https://www.mdpi.com/2073-4360/13/10/1539 |
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