A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice

A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice

Background: Paclitaxel-induced peripheral neuropathy (PIPN) is a major adverse effect of this chemotherapeutic agent that is used in the treatment of a number of solid malignancies. PIPN leads notably to burning pain, cold and mechanical allodynia. PIPN is thought to be a consequence of alterations...

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Bibliographic Details
Main Authors: Martial Caillaud, Nipa H. Patel, Wisam Toma, Alyssa White, Danielle Thompson, Jared Mann, Tammy H. Tran, Jane L. Roberts, Justin L. Poklis, John W. Bigbee, Xianjun Fang, David A. Gewirtz, M. Imad Damaj
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
fenofibrate
PPAR-α
paclitaxel
neuropathic pain
peripheral neuropathy
Online Access:https://www.mdpi.com/2072-6694/13/1/69

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