COL10A1 allows stratification of invasiveness of colon cancer and associates to extracellular matrix and immune cell enrichment in the tumor parenchyma

COL10A1 allows stratification of invasiveness of colon cancer and associates to extracellular matrix and immune cell enrichment in the tumor parenchyma

BackgroundTreatment options for metastatic colorectal cancer (CRC) are mostly ineffective. We present new evidence that tumor tissue collagen type X alpha 1 (COL10A1) is a relevant candidate biomarker to improve this dilemma.MethodsSeveral public databases had been screened to observe COL10A1 expres...

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Bibliographic Details
Main Authors: Ulf D. Kahlert, Wenjie Shi, Marco Strecker, Lorenz A. Scherpinski, Thomas Wartmann, Maximilian Dölling, Aristotelis Perrakis, Borna Relja, Miriam Mengoni, Andreas Braun, Roland S. Croner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
colon cancer
biomarker
tumor microenvironment
collagen type 10
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1007514/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1007514/full

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