Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome

Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome

Kinesin-binding protein (KBP; KIF1BP; KIAA1279) functions as a regulator for a subset of kinesins, many of which play important roles in neural development. Previous studies have shown that KBP is expressed in nearly all tissue with cytoplasmic localization. Autosomal recessive mutations in KIAA1279...

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Bibliographic Details
Main Authors: Hsin-Yun Chang, Haw-Yuan Cheng, Ai-Ni Tsao, Chen Liu, Jin-Wu Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
kinesin-binding protein (KBP)
KIF1BP
KIAA1279
Goldberg-Shprintzen syndrome
cortical development
neuronal migration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00265/full

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