THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION
The review presents the analysis and possible ways of solving the issues of treatment of age related macular degeneration (AMD) based on pharmacogenetic approaches. The AMD problem is relevant because of the growing number of resistant neovascular membranes, an increase in the number of older-age pa...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/156 |
| _version_ | 1797878357133623296 |
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| author | N. A. Bakunina S. N. Shcherbo L. N. Kolesnikova |
| author_facet | N. A. Bakunina S. N. Shcherbo L. N. Kolesnikova |
| author_sort | N. A. Bakunina |
| collection | DOAJ |
| description | The review presents the analysis and possible ways of solving the issues of treatment of age related macular degeneration (AMD) based on pharmacogenetic approaches. The AMD problem is relevant because of the growing number of resistant neovascular membranes, an increase in the number of older-age patients, and a large number of complications from frequently used anti VEGF therapy as described in the literature. According to literary data, currently the most probable genes whose polymorphisms can affect the metabolism of drugs used, and hence the tactics of AMD treatment are: 1) CFH gene [complement factor H, chromosome 1q32 locus)]; 2) IL-8 gene; 3) ARMS2 gene of increased sensitivity to AMD; 4) VEGF-A gene; 5) NR3C1 gene. The need for diagnostic pharmacogenetic panels to select targeted AMD therapy is discussed. For citation: Bakunina N.А., Shcherbo S.N., Kolesnikova L.N. The prognostic value of pharmacological and genetic testing in medical therapy of age-related macular degeneration. Russian ophthalmological journal. 2018; 11 (2): 58-61. doi: 10.21516/2072-0076-2018-11-2-58-61 (In Russian). |
| first_indexed | 2024-04-10T02:31:24Z |
| format | Article |
| id | doaj.art-64cb2c511b46448782f8158f99543ce6 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:31:24Z |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-64cb2c511b46448782f8158f99543ce62023-03-13T07:54:29ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-01112586110.21516/2072-0076-2018-11-2-58-61156THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATIONN. A. Bakunina0S. N. Shcherbo1L. N. Kolesnikova2ГКБ № 1 им. Н.И. Пирогова, МоскваФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И.Пирогова» Минздрава России, МоскваГКБ № 1 им. Н.И. Пирогова, МоскваThe review presents the analysis and possible ways of solving the issues of treatment of age related macular degeneration (AMD) based on pharmacogenetic approaches. The AMD problem is relevant because of the growing number of resistant neovascular membranes, an increase in the number of older-age patients, and a large number of complications from frequently used anti VEGF therapy as described in the literature. According to literary data, currently the most probable genes whose polymorphisms can affect the metabolism of drugs used, and hence the tactics of AMD treatment are: 1) CFH gene [complement factor H, chromosome 1q32 locus)]; 2) IL-8 gene; 3) ARMS2 gene of increased sensitivity to AMD; 4) VEGF-A gene; 5) NR3C1 gene. The need for diagnostic pharmacogenetic panels to select targeted AMD therapy is discussed. For citation: Bakunina N.А., Shcherbo S.N., Kolesnikova L.N. The prognostic value of pharmacological and genetic testing in medical therapy of age-related macular degeneration. Russian ophthalmological journal. 2018; 11 (2): 58-61. doi: 10.21516/2072-0076-2018-11-2-58-61 (In Russian).https://roj.igb.ru/jour/article/view/156возрастная макулярная дегенерацияфармакогенетикаанти-vegf терапияполиморфизмы геновфармакогенетикаage-related macular degenerationpharmacogeneticsanti-vegf therapygenes polymorphisms |
| spellingShingle | N. A. Bakunina S. N. Shcherbo L. N. Kolesnikova THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION Российский офтальмологический журнал возрастная макулярная дегенерация фармакогенетика анти-vegf терапия полиморфизмы генов фармакогенетика age-related macular degeneration pharmacogenetics anti-vegf therapy genes polymorphisms |
| title | THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION |
| title_full | THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION |
| title_fullStr | THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION |
| title_full_unstemmed | THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION |
| title_short | THE PROGNOSTIC VALUE OF PHARMACOLOGICAL AND GENETIC TESTING IN MEDICAL THERAPY OF AGE-RELATED MACULAR DEGENERATION |
| title_sort | prognostic value of pharmacological and genetic testing in medical therapy of age related macular degeneration |
| topic | возрастная макулярная дегенерация фармакогенетика анти-vegf терапия полиморфизмы генов фармакогенетика age-related macular degeneration pharmacogenetics anti-vegf therapy genes polymorphisms |
| url | https://roj.igb.ru/jour/article/view/156 |
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