Driver and actionable mutations in younger patients with lung cancer - are we searching properly?
Aims. The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations. Methods. We collected retrospective data on patients under 40 years diagnosed with lung cancer...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2023-06-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202302-0008_driver-and-actionable-mutations-in-younger-patients-with-lung-cancer-are-we-searching-properly.php |
| _version_ | 1797804260636753920 |
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| author | Monika Bratova Kristian Brat Zdenek Pavlovsky Jiri Sana Ondrej Slaby |
| author_facet | Monika Bratova Kristian Brat Zdenek Pavlovsky Jiri Sana Ondrej Slaby |
| author_sort | Monika Bratova |
| collection | DOAJ |
| description | Aims. The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations. Methods. We collected retrospective data on patients under 40 years diagnosed with lung cancer (NSCLC or small-cell lung cancer) from 2011-2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic. Tumor tissue of these patients was analysed by next-generation sequencing (NGS, a panel of 550 variants in 19 genes). Demographic characteristics, smoking history, histology, molecular-genetic results and clinical stage of the disesase were recorded in all eligible patients from accessible medical databases. Results. Of 17 identified patients in only 8 cases was successful NGS carried out due to lack of sufficient good quality material in the other cases. The most frequently found molecular genetic changes were EGFR, RICTOR and HER2 amplification and MET and FGFR1 amplification. In addition, we found rare pathogenic variants in BRAF and PIK3CA genes. Actionable variants were detected in 75% patients. Conclusion. We detected very frequent driver and potentially actionable alterations in young patients with lung cancer. This suggests different mechanisms of carcinogenesis in these patients and indicates that they might benefit more from a specific approach than older lung cancer patients. |
| first_indexed | 2024-03-13T05:34:31Z |
| format | Article |
| id | doaj.art-64cba5bec937483e8dcb437b4f07ee81 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-03-13T05:34:31Z |
| publishDate | 2023-06-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-64cba5bec937483e8dcb437b4f07ee812023-06-14T11:15:48ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212023-06-01167215215610.5507/bp.2023.012bio-202302-0008Driver and actionable mutations in younger patients with lung cancer - are we searching properly?Monika Bratova0Kristian Brat1Zdenek Pavlovsky2Jiri Sana3Ondrej Slaby4Department of Respiratory Diseases, University Hospital Brno, Brno, Czech RepublicDepartment of Respiratory Diseases, University Hospital Brno, Brno, Czech RepublicDepartment of Pathology, University Hospital Brno, Brno, Czech RepublicDepartment of Pathology, University Hospital Brno, Brno, Czech RepublicDepartment of Pathology, University Hospital Brno, Brno, Czech RepublicAims. The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations. Methods. We collected retrospective data on patients under 40 years diagnosed with lung cancer (NSCLC or small-cell lung cancer) from 2011-2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic. Tumor tissue of these patients was analysed by next-generation sequencing (NGS, a panel of 550 variants in 19 genes). Demographic characteristics, smoking history, histology, molecular-genetic results and clinical stage of the disesase were recorded in all eligible patients from accessible medical databases. Results. Of 17 identified patients in only 8 cases was successful NGS carried out due to lack of sufficient good quality material in the other cases. The most frequently found molecular genetic changes were EGFR, RICTOR and HER2 amplification and MET and FGFR1 amplification. In addition, we found rare pathogenic variants in BRAF and PIK3CA genes. Actionable variants were detected in 75% patients. Conclusion. We detected very frequent driver and potentially actionable alterations in young patients with lung cancer. This suggests different mechanisms of carcinogenesis in these patients and indicates that they might benefit more from a specific approach than older lung cancer patients.https://biomed.papers.upol.cz/artkey/bio-202302-0008_driver-and-actionable-mutations-in-younger-patients-with-lung-cancer-are-we-searching-properly.phplung canceryoung patientdrivermutation |
| spellingShingle | Monika Bratova Kristian Brat Zdenek Pavlovsky Jiri Sana Ondrej Slaby Driver and actionable mutations in younger patients with lung cancer - are we searching properly? Biomedical Papers lung cancer young patient driver mutation |
| title | Driver and actionable mutations in younger patients with lung cancer - are we searching properly? |
| title_full | Driver and actionable mutations in younger patients with lung cancer - are we searching properly? |
| title_fullStr | Driver and actionable mutations in younger patients with lung cancer - are we searching properly? |
| title_full_unstemmed | Driver and actionable mutations in younger patients with lung cancer - are we searching properly? |
| title_short | Driver and actionable mutations in younger patients with lung cancer - are we searching properly? |
| title_sort | driver and actionable mutations in younger patients with lung cancer are we searching properly |
| topic | lung cancer young patient driver mutation |
| url | https://biomed.papers.upol.cz/artkey/bio-202302-0008_driver-and-actionable-mutations-in-younger-patients-with-lung-cancer-are-we-searching-properly.php |
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