Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment
In the present study, we explore the role of attachment for microstructural white matter (WM) changes in adolescents with anorexia nervosa (AN) before and after exposure to short-term and nutritional treatment. The case sample consisted of 22 female adolescent inpatients with AN (mean age: 15.2 ± 1....
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| Formáid: | Alt |
| Teanga: | English |
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MDPI AG
2023-05-01
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| Sraith: | Brain Sciences |
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| Rochtain ar líne: | https://www.mdpi.com/2076-3425/13/5/798 |
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| author | Manuela Gander Lukas Lenhart Ruth Steiger Anna Buchheim Stephanie Mangesius Christoph Birkl Nina Haid-Stecher Martin Fuchs Anna Libal Agnieszka Dabkowska-Mika Elke Ruth Gizewski Kathrin Sevecke |
| author_facet | Manuela Gander Lukas Lenhart Ruth Steiger Anna Buchheim Stephanie Mangesius Christoph Birkl Nina Haid-Stecher Martin Fuchs Anna Libal Agnieszka Dabkowska-Mika Elke Ruth Gizewski Kathrin Sevecke |
| author_sort | Manuela Gander |
| collection | DOAJ |
| description | In the present study, we explore the role of attachment for microstructural white matter (WM) changes in adolescents with anorexia nervosa (AN) before and after exposure to short-term and nutritional treatment. The case sample consisted of 22 female adolescent inpatients with AN (mean age: 15.2 ± 1.2 years) and the control sample were 18 gender-matched healthy adolescents (mean age: 16.8 ± 0.9 years). We performed a 3T MRI in the patient group during the acute state of AN and after weight restoration (duration: 2.6 ± 1 months) and compared the data to a healthy control group. To classify attachment patterns, we used the Adult Attachment Projective Picture System. In the patient sample, over 50% were classified with an attachment trauma/unresolved attachment status. Prior to treatment exposure, fractional anisotropy (FA) reductions and concordant mean diffusivity (MD) increases were evident in the fornix, the corpus callosum and WM regions of the thalamus, which normalized in the corpus callosum and the fornix post-therapy in the total patient sample (<i>p</i> < 0.002). In the acute state, patients with an attachment trauma demonstrated significant FA decreases compared to healthy controls, but no MD increases, in the corpus callosum and cingulum bilaterally, which remained decreased after therapy. Attachment patterns seem to be associated with region-specific changes of WM alterations in AN. |
| first_indexed | 2024-03-11T03:53:44Z |
| format | Article |
| id | doaj.art-64cbff7393d641ffb642063410910771 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T03:53:44Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-64cbff7393d641ffb6420634109107712023-11-18T00:43:00ZengMDPI AGBrain Sciences2076-34252023-05-0113579810.3390/brainsci13050798Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional TreatmentManuela Gander0Lukas Lenhart1Ruth Steiger2Anna Buchheim3Stephanie Mangesius4Christoph Birkl5Nina Haid-Stecher6Martin Fuchs7Anna Libal8Agnieszka Dabkowska-Mika9Elke Ruth Gizewski10Kathrin Sevecke11Institute of Psychology, Leopold-Franzens-University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaInstitute of Psychology, Leopold-Franzens-University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Child and Adolescent Psychiatry, Tirol Kliniken, 6060 Hall in Tirol, AustriaDepartment of Child and Adolescent Psychiatry, Tirol Kliniken, 6060 Hall in Tirol, AustriaDepartment of Child and Adolescent Psychiatry, Tirol Kliniken, 6060 Hall in Tirol, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Child and Adolescent Psychiatry, Tirol Kliniken, 6060 Hall in Tirol, AustriaIn the present study, we explore the role of attachment for microstructural white matter (WM) changes in adolescents with anorexia nervosa (AN) before and after exposure to short-term and nutritional treatment. The case sample consisted of 22 female adolescent inpatients with AN (mean age: 15.2 ± 1.2 years) and the control sample were 18 gender-matched healthy adolescents (mean age: 16.8 ± 0.9 years). We performed a 3T MRI in the patient group during the acute state of AN and after weight restoration (duration: 2.6 ± 1 months) and compared the data to a healthy control group. To classify attachment patterns, we used the Adult Attachment Projective Picture System. In the patient sample, over 50% were classified with an attachment trauma/unresolved attachment status. Prior to treatment exposure, fractional anisotropy (FA) reductions and concordant mean diffusivity (MD) increases were evident in the fornix, the corpus callosum and WM regions of the thalamus, which normalized in the corpus callosum and the fornix post-therapy in the total patient sample (<i>p</i> < 0.002). In the acute state, patients with an attachment trauma demonstrated significant FA decreases compared to healthy controls, but no MD increases, in the corpus callosum and cingulum bilaterally, which remained decreased after therapy. Attachment patterns seem to be associated with region-specific changes of WM alterations in AN.https://www.mdpi.com/2076-3425/13/5/798anorexia nervosawhite matterfractional anisotropyattachmentadolescence |
| spellingShingle | Manuela Gander Lukas Lenhart Ruth Steiger Anna Buchheim Stephanie Mangesius Christoph Birkl Nina Haid-Stecher Martin Fuchs Anna Libal Agnieszka Dabkowska-Mika Elke Ruth Gizewski Kathrin Sevecke Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment Brain Sciences anorexia nervosa white matter fractional anisotropy attachment adolescence |
| title | Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment |
| title_full | Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment |
| title_fullStr | Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment |
| title_full_unstemmed | Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment |
| title_short | Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment |
| title_sort | attachment trauma is associated with white matter fiber microstructural alterations in adolescents with anorexia nervosa before and after exposure to psychotherapeutic and nutritional treatment |
| topic | anorexia nervosa white matter fractional anisotropy attachment adolescence |
| url | https://www.mdpi.com/2076-3425/13/5/798 |
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