Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest...
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| Materialtyp: | Artikel |
| Språk: | English |
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Taylor & Francis Group
2023-12-01
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| Serie: | Expert Review of Vaccines |
| Ämnen: | |
| Länkar: | http://dx.doi.org/10.1080/14760584.2023.2245890 |
| _version_ | 1827813161490710528 |
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| author | Thomas L. Richie L.W. Preston Church Tooba Murshedkar Peter F. Billingsley Eric R. James Mei-Chun Chen Yonas Abebe Natasha KC Sumana Chakravarty David Dolberg Sara A. Healy Halimatou Diawara Mahamadou S. Sissoko Issaka Sagara David M. Cook Judith E. Epstein Benjamin Mordmüller Melissa Kapulu Andrea Kreidenweiss Blandine Franke-Fayard Selidji T. Agnandji María-Silvia A. López Mikue Matthew B.B. McCall Laura Steinhardt Martina Oneko Ally Olotu Ashley M. Vaughan James G. Kublin Sean C. Murphy Said Jongo Marcel Tanner Sodiomon B. Sirima Matthew B. Laurens Claudia Daubenberger Joana C. Silva Kirsten E. Lyke Chris J. Janse Meta Roestenberg Robert W. Sauerwein Salim Abdulla Alassane Dicko Stefan H. I. Kappe B. Kim Lee Sim Patrick E. Duffy Peter G. Kremsner Stephen L. Hoffman |
| author_facet | Thomas L. Richie L.W. Preston Church Tooba Murshedkar Peter F. Billingsley Eric R. James Mei-Chun Chen Yonas Abebe Natasha KC Sumana Chakravarty David Dolberg Sara A. Healy Halimatou Diawara Mahamadou S. Sissoko Issaka Sagara David M. Cook Judith E. Epstein Benjamin Mordmüller Melissa Kapulu Andrea Kreidenweiss Blandine Franke-Fayard Selidji T. Agnandji María-Silvia A. López Mikue Matthew B.B. McCall Laura Steinhardt Martina Oneko Ally Olotu Ashley M. Vaughan James G. Kublin Sean C. Murphy Said Jongo Marcel Tanner Sodiomon B. Sirima Matthew B. Laurens Claudia Daubenberger Joana C. Silva Kirsten E. Lyke Chris J. Janse Meta Roestenberg Robert W. Sauerwein Salim Abdulla Alassane Dicko Stefan H. I. Kappe B. Kim Lee Sim Patrick E. Duffy Peter G. Kremsner Stephen L. Hoffman |
| author_sort | Thomas L. Richie |
| collection | DOAJ |
| description | Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. Areas covered Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes > 30 clinical trials of PfSPZ vaccines in the U.S.A., Europe, Africa, and Asia, based on first-hand knowledge of the trials and PubMed searches of ‘sporozoites,’ ‘malaria,’ and ‘vaccines.’ Expert opinion First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection (CHMI) and provide 18-19 months protection without boosting in Africa. Second generation chemo-attenuated PfSPZ are more potent, 100% efficacious against stringent heterologous (variant strain) CHMI, but require a co-administered drug, raising safety concerns. Third generation, late liver stage-arresting, replication competent (LARC), genetically-attenuated PfSPZ are expected to be both safe and highly efficacious. Overall, PfSPZ vaccines meet safety, tolerability, and efficacy requirements for protecting pregnant women and travelers, with licensure for these populations possible within five years. Protecting children and mass vaccination programs to block transmission and eliminate malaria are long-term objectives. |
| first_indexed | 2024-03-11T23:28:52Z |
| format | Article |
| id | doaj.art-64ccc130995e4fbda0570808ef7ca47d |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:28:52Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-64ccc130995e4fbda0570808ef7ca47d2023-09-20T10:33:44ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952023-12-010010.1080/14760584.2023.22458902245890Sporozoite immunization: Innovative Translational Science to Support the Fight against malariaThomas L. Richie0L.W. Preston Church1Tooba Murshedkar2Peter F. Billingsley3Eric R. James4Mei-Chun Chen5Yonas Abebe6Natasha KC7Sumana Chakravarty8David Dolberg9Sara A. Healy10Halimatou Diawara11Mahamadou S. Sissoko12Issaka Sagara13David M. Cook14Judith E. Epstein15Benjamin Mordmüller16Melissa Kapulu17Andrea Kreidenweiss18Blandine Franke-Fayard19Selidji T. Agnandji20María-Silvia A. López Mikue21Matthew B.B. McCall22Laura Steinhardt23Martina Oneko24Ally Olotu25Ashley M. Vaughan26James G. Kublin27Sean C. Murphy28Said Jongo29Marcel Tanner30Sodiomon B. Sirima31Matthew B. Laurens32Claudia Daubenberger33Joana C. Silva34Kirsten E. Lyke35Chris J. Janse36Meta Roestenberg37Robert W. Sauerwein38Salim Abdulla39Alassane Dicko40Stefan H. I. Kappe41B. Kim Lee Sim42Patrick E. Duffy43Peter G. Kremsner44Stephen L. Hoffman45Sanaria IncSanaria IncSanaria IncSanaria IncSanaria IncSanaria IncSanaria IncSanaria IncSanaria IncSanaria IncNational Institutes of HealthUniversity of Science, Techniques and Technologies of BamakoUniversity of Science, Techniques and Technologies of BamakoUniversity of Science, Techniques and Technologies of BamakoNational Institutes of HealthNational Institutes of HealthRadboud university medical centerKEMRI-Wellcome Research ProgrammeUniversitätsklinikum TübingenLeiden University Center for Infectious Diseases, Leiden University Medical CenterLeiden University Center for Infectious Diseases, Leiden University Medical CenterGovernment of Equatorial GuineaRadboud university medical centerCenters for Disease Control and PreventionCentre for Global Health ResearchIfakara Health InstituteSeattle Children’s Research InstituteUniversity of WashingtonUniversity of WashingtonIfakara Health Institutewiss Tropical and Public Health InstituteGroupe de Recherche Action en Santé (GRAS)University of Maryland School of Medicinewiss Tropical and Public Health InstituteUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineLeiden University Center for Infectious Diseases, Leiden University Medical CenterLeiden University Center for Infectious Diseases, Leiden University Medical CenterRadboud university medical centerIfakara Health InstituteUniversity of Science, Techniques and Technologies of BamakoSeattle Children’s Research InstituteSanaria IncNational Institutes of HealthUniversitätsklinikum TübingenSanaria IncIntroduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. Areas covered Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes > 30 clinical trials of PfSPZ vaccines in the U.S.A., Europe, Africa, and Asia, based on first-hand knowledge of the trials and PubMed searches of ‘sporozoites,’ ‘malaria,’ and ‘vaccines.’ Expert opinion First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection (CHMI) and provide 18-19 months protection without boosting in Africa. Second generation chemo-attenuated PfSPZ are more potent, 100% efficacious against stringent heterologous (variant strain) CHMI, but require a co-administered drug, raising safety concerns. Third generation, late liver stage-arresting, replication competent (LARC), genetically-attenuated PfSPZ are expected to be both safe and highly efficacious. Overall, PfSPZ vaccines meet safety, tolerability, and efficacy requirements for protecting pregnant women and travelers, with licensure for these populations possible within five years. Protecting children and mass vaccination programs to block transmission and eliminate malaria are long-term objectives.http://dx.doi.org/10.1080/14760584.2023.2245890sporozoitesvaccinespfspzpfspz vaccinepfspz-cvacpfspz-larc2 vaccinemalaria vaccineslive attenuated vaccinesreviewdirect venous inoculation |
| spellingShingle | Thomas L. Richie L.W. Preston Church Tooba Murshedkar Peter F. Billingsley Eric R. James Mei-Chun Chen Yonas Abebe Natasha KC Sumana Chakravarty David Dolberg Sara A. Healy Halimatou Diawara Mahamadou S. Sissoko Issaka Sagara David M. Cook Judith E. Epstein Benjamin Mordmüller Melissa Kapulu Andrea Kreidenweiss Blandine Franke-Fayard Selidji T. Agnandji María-Silvia A. López Mikue Matthew B.B. McCall Laura Steinhardt Martina Oneko Ally Olotu Ashley M. Vaughan James G. Kublin Sean C. Murphy Said Jongo Marcel Tanner Sodiomon B. Sirima Matthew B. Laurens Claudia Daubenberger Joana C. Silva Kirsten E. Lyke Chris J. Janse Meta Roestenberg Robert W. Sauerwein Salim Abdulla Alassane Dicko Stefan H. I. Kappe B. Kim Lee Sim Patrick E. Duffy Peter G. Kremsner Stephen L. Hoffman Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria Expert Review of Vaccines sporozoites vaccines pfspz pfspz vaccine pfspz-cvac pfspz-larc2 vaccine malaria vaccines live attenuated vaccines review direct venous inoculation |
| title | Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria |
| title_full | Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria |
| title_fullStr | Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria |
| title_full_unstemmed | Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria |
| title_short | Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria |
| title_sort | sporozoite immunization innovative translational science to support the fight against malaria |
| topic | sporozoites vaccines pfspz pfspz vaccine pfspz-cvac pfspz-larc2 vaccine malaria vaccines live attenuated vaccines review direct venous inoculation |
| url | http://dx.doi.org/10.1080/14760584.2023.2245890 |
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