A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse
Sustanon (SUS) consists of testosterone propionate (TP), testosterone phenylpropionate (TPP), testosterone isocaproate (TIC) and testosterone decanoate (TD) which is generally used as a medication to treat the testosterone deficiency in men. Misuse of SUS to enhance the ability of the athletes can b...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Sensing and Bio-Sensing Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180423000090 |
| _version_ | 1797818715386937344 |
|---|---|
| author | Ali R. Jalalvand |
| author_facet | Ali R. Jalalvand |
| author_sort | Ali R. Jalalvand |
| collection | DOAJ |
| description | Sustanon (SUS) consists of testosterone propionate (TP), testosterone phenylpropionate (TPP), testosterone isocaproate (TIC) and testosterone decanoate (TD) which is generally used as a medication to treat the testosterone deficiency in men. Misuse of SUS to enhance the ability of the athletes can be a very serious risk for their health which is discouraged. Therefore, the main aim of this work was based on developing a novel biosensing system for determination of different types of testosterones in SUS to monitor it. A rotating glassy carbon electrode (GCE) was modified with fullerene C60-multiwalled carbon nanotubes-ionic liquid (C60-MWCNTs-IL) and used as the working electrode for recording second-order hydrodynamic square wave voltammetric (hydrodynamic SWV) data at different step potentials including 0.02, 0.025, 0.03, 0.035, 0.04 and 0.045 V as a sensitive method. Different types of testosterones were extracted and preconcentrated by quadruple templates molecularly imprinted polymers (QTMIPs) and they were determined by C60-MWCNTs-IL/GCE. The testosterones showed severely overlapped peaks at the surface of C60-MWCNTs-IL/GCE which were resolved by three-way calibration based on second-order hydrodynamic SWV data. Therefore, a novel sensor assisted by QTMIPs and second-order calibration methods was developed which had a very good performance for the analysis of synthetic and real matrices in simultaneous determination of TP, TPP, TIC and TD with aim of monitoring the SUS. |
| first_indexed | 2024-03-13T09:12:09Z |
| format | Article |
| id | doaj.art-64ce152047f6474d9bea45d8eee965c2 |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-03-13T09:12:09Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-64ce152047f6474d9bea45d8eee965c22023-05-27T04:25:16ZengElsevierSensing and Bio-Sensing Research2214-18042023-06-0140100557A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuseAli R. Jalalvand0Research Center of Oils and Fats, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, IranSustanon (SUS) consists of testosterone propionate (TP), testosterone phenylpropionate (TPP), testosterone isocaproate (TIC) and testosterone decanoate (TD) which is generally used as a medication to treat the testosterone deficiency in men. Misuse of SUS to enhance the ability of the athletes can be a very serious risk for their health which is discouraged. Therefore, the main aim of this work was based on developing a novel biosensing system for determination of different types of testosterones in SUS to monitor it. A rotating glassy carbon electrode (GCE) was modified with fullerene C60-multiwalled carbon nanotubes-ionic liquid (C60-MWCNTs-IL) and used as the working electrode for recording second-order hydrodynamic square wave voltammetric (hydrodynamic SWV) data at different step potentials including 0.02, 0.025, 0.03, 0.035, 0.04 and 0.045 V as a sensitive method. Different types of testosterones were extracted and preconcentrated by quadruple templates molecularly imprinted polymers (QTMIPs) and they were determined by C60-MWCNTs-IL/GCE. The testosterones showed severely overlapped peaks at the surface of C60-MWCNTs-IL/GCE which were resolved by three-way calibration based on second-order hydrodynamic SWV data. Therefore, a novel sensor assisted by QTMIPs and second-order calibration methods was developed which had a very good performance for the analysis of synthetic and real matrices in simultaneous determination of TP, TPP, TIC and TD with aim of monitoring the SUS.http://www.sciencedirect.com/science/article/pii/S2214180423000090SustanonTestosteronesQuadruple templates molecularly imprinted polymersSensor |
| spellingShingle | Ali R. Jalalvand A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse Sensing and Bio-Sensing Research Sustanon Testosterones Quadruple templates molecularly imprinted polymers Sensor |
| title | A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse |
| title_full | A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse |
| title_fullStr | A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse |
| title_full_unstemmed | A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse |
| title_short | A novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second-order calibration methods for detection of Sustanon abuse |
| title_sort | novel quadruple templates molecularly imprinted polymer electrochemical sensor assisted by second order calibration methods for detection of sustanon abuse |
| topic | Sustanon Testosterones Quadruple templates molecularly imprinted polymers Sensor |
| url | http://www.sciencedirect.com/science/article/pii/S2214180423000090 |
| work_keys_str_mv | AT alirjalalvand anovelquadrupletemplatesmolecularlyimprintedpolymerelectrochemicalsensorassistedbysecondordercalibrationmethodsfordetectionofsustanonabuse AT alirjalalvand novelquadrupletemplatesmolecularlyimprintedpolymerelectrochemicalsensorassistedbysecondordercalibrationmethodsfordetectionofsustanonabuse |