Bioactive compounds by microalgae and potentials for the management of some human disease conditions
Microalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-cultur...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2023-01-01
|
| Series: | AIMS Microbiology |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/microbiol.2023004?viewType=HTML |
| _version_ | 1827997796751376384 |
|---|---|
| author | Chijioke Nwoye Eze Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Johnson k. Ndukwe Ogueri Nwaiwu Helen Onyeaka |
| author_facet | Chijioke Nwoye Eze Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Johnson k. Ndukwe Ogueri Nwaiwu Helen Onyeaka |
| author_sort | Chijioke Nwoye Eze |
| collection | DOAJ |
| description | Microalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-culture systems. Some of these bioactive compounds (such as polysaccharides, phycobiliproteins and lipids) are produced during their active growth phase. They appear to have antibacterial, antifungal, antiviral, antioxidative, anticancer, neuroprotective and chemo-preventive activities. These properties confer on microalgae the potential for use in the treatment and/or management of several neurologic and cell dysfunction-related disease conditions, including Alzheimer's disease (AD), AIDS and COVID-19, as shown in this review. Although several health benefits have been highlighted, there appears to be a consensus in the literature that the field of microalgae is still fledgling, and more research needs to be carried out to ascertain the mechanisms of action that underpin the effectiveness of microalgal compounds. In this review, two biosynthetic pathways were modeled to help elucidate the mode of action of the bioactive compounds from microalgae and their products. These are carotenoid and phycobilin proteins biosynthetic pathways. The education of the public on the importance of microalgae backed with empirical scientific evidence will go a long way to ensure that the benefits from research investigations are quickly rolled out. The potential application of these microalgae to some human disease conditions was highlighted. |
| first_indexed | 2024-04-10T05:33:22Z |
| format | Article |
| id | doaj.art-64cfaa5b8185473fbedfffe06be4d7c8 |
| institution | Directory Open Access Journal |
| issn | 2471-1888 |
| language | English |
| last_indexed | 2024-04-10T05:33:22Z |
| publishDate | 2023-01-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Microbiology |
| spelling | doaj.art-64cfaa5b8185473fbedfffe06be4d7c82023-03-07T01:12:26ZengAIMS PressAIMS Microbiology2471-18882023-01-0191557410.3934/microbiol.2023004Bioactive compounds by microalgae and potentials for the management of some human disease conditionsChijioke Nwoye Eze 0Chukwu Kenechi Onyejiaka1Stella Amarachi Ihim 2Thecla Okeahunwa Ayoka 3Chiugo Claret Aduba4Chukwu Kenechi Onyejiaka 5Stella Amarachi Ihim6Thecla Okeahunwa Ayoka7 Chiugo Claret Aduba 8Johnson k. Ndukwe9Ogueri Nwaiwu 10Helen Onyeaka111. Department of Science Laboratory Technology, University of Nigeria Nsukka2. Department of Microbiology, University of Nigeria Nsukka3. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical, University of Nigeria Nsukka4. Department of Biochemistry, University of Nigeria Nsukka1. Department of Science Laboratory Technology, University of Nigeria Nsukka2. Department of Microbiology, University of Nigeria Nsukka3. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical, University of Nigeria Nsukka4. Department of Biochemistry, University of Nigeria Nsukka1. Department of Science Laboratory Technology, University of Nigeria Nsukka2. Department of Microbiology, University of Nigeria Nsukka5. UNESCO International Centre for Biotechnology, University of Nigeria Nsukka6. School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom6. School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United KingdomMicroalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-culture systems. Some of these bioactive compounds (such as polysaccharides, phycobiliproteins and lipids) are produced during their active growth phase. They appear to have antibacterial, antifungal, antiviral, antioxidative, anticancer, neuroprotective and chemo-preventive activities. These properties confer on microalgae the potential for use in the treatment and/or management of several neurologic and cell dysfunction-related disease conditions, including Alzheimer's disease (AD), AIDS and COVID-19, as shown in this review. Although several health benefits have been highlighted, there appears to be a consensus in the literature that the field of microalgae is still fledgling, and more research needs to be carried out to ascertain the mechanisms of action that underpin the effectiveness of microalgal compounds. In this review, two biosynthetic pathways were modeled to help elucidate the mode of action of the bioactive compounds from microalgae and their products. These are carotenoid and phycobilin proteins biosynthetic pathways. The education of the public on the importance of microalgae backed with empirical scientific evidence will go a long way to ensure that the benefits from research investigations are quickly rolled out. The potential application of these microalgae to some human disease conditions was highlighted.https://www.aimspress.com/article/doi/10.3934/microbiol.2023004?viewType=HTMLactive compoundscarotenoidsalzheimer's diseaseoxidative stress |
| spellingShingle | Chijioke Nwoye Eze Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Chukwu Kenechi Onyejiaka Stella Amarachi Ihim Thecla Okeahunwa Ayoka Chiugo Claret Aduba Johnson k. Ndukwe Ogueri Nwaiwu Helen Onyeaka Bioactive compounds by microalgae and potentials for the management of some human disease conditions AIMS Microbiology active compounds carotenoids alzheimer's disease oxidative stress |
| title | Bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| title_full | Bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| title_fullStr | Bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| title_full_unstemmed | Bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| title_short | Bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| title_sort | bioactive compounds by microalgae and potentials for the management of some human disease conditions |
| topic | active compounds carotenoids alzheimer's disease oxidative stress |
| url | https://www.aimspress.com/article/doi/10.3934/microbiol.2023004?viewType=HTML |
| work_keys_str_mv | AT chijiokenwoyeeze bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT chukwukenechionyejiaka bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT stellaamarachiihim bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT theclaokeahunwaayoka bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT chiugoclaretaduba bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT chukwukenechionyejiaka bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT stellaamarachiihim bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT theclaokeahunwaayoka bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT chiugoclaretaduba bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT johnsonkndukwe bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT oguerinwaiwu bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions AT helenonyeaka bioactivecompoundsbymicroalgaeandpotentialsforthemanagementofsomehumandiseaseconditions |