LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling
Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.637852/full |
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| author | Gayathri K. Natarajan Jyotsna Mishra Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok |
| author_facet | Gayathri K. Natarajan Jyotsna Mishra Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok |
| author_sort | Gayathri K. Natarajan |
| collection | DOAJ |
| description | Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease. |
| first_indexed | 2024-12-13T23:45:20Z |
| format | Article |
| id | doaj.art-64d2532556294e65ac31b7e630bdf10e |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T23:45:20Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-64d2532556294e65ac31b7e630bdf10e2022-12-21T23:26:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.637852637852LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular SignalingGayathri K. Natarajan0Jyotsna Mishra1Amadou K. S. Camara2Amadou K. S. Camara3Amadou K. S. Camara4Amadou K. S. Camara5Wai-Meng Kwok6Wai-Meng Kwok7Wai-Meng Kwok8Wai-Meng Kwok9Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United StatesCancer Center, Medical College of Wisconsin, Milwaukee, WI, United StatesCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United StatesCancer Center, Medical College of Wisconsin, Milwaukee, WI, United StatesCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United StatesNearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.https://www.frontiersin.org/articles/10.3389/fphys.2021.637852/fullleucine-zipper EF-hand containing transmembrane 1mitochondrial calcium hydrogen exchangermitochondrial potassium hydrogen exchangermitochondrial calcium handlingcarboxy-terminal-modulator-proteinWolf-Hirschhorn syndrome |
| spellingShingle | Gayathri K. Natarajan Jyotsna Mishra Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Amadou K. S. Camara Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok Wai-Meng Kwok LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling Frontiers in Physiology leucine-zipper EF-hand containing transmembrane 1 mitochondrial calcium hydrogen exchanger mitochondrial potassium hydrogen exchanger mitochondrial calcium handling carboxy-terminal-modulator-protein Wolf-Hirschhorn syndrome |
| title | LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling |
| title_full | LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling |
| title_fullStr | LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling |
| title_full_unstemmed | LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling |
| title_short | LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling |
| title_sort | letm1 a single entity with diverse impact on mitochondrial metabolism and cellular signaling |
| topic | leucine-zipper EF-hand containing transmembrane 1 mitochondrial calcium hydrogen exchanger mitochondrial potassium hydrogen exchanger mitochondrial calcium handling carboxy-terminal-modulator-protein Wolf-Hirschhorn syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.637852/full |
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