A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies
With an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise. Every year, millions of animals are used for experimental testing during which these suffer from pain and are then...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=4;spage=165;epage=171;aulast=Husain |
| _version_ | 1797222316340412416 |
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| author | Asif Husain Dhanalekshmi U Meenakshi Aftab Ahmad Neelima Shrivastava Shah A Khan |
| author_facet | Asif Husain Dhanalekshmi U Meenakshi Aftab Ahmad Neelima Shrivastava Shah A Khan |
| author_sort | Asif Husain |
| collection | DOAJ |
| description | With an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise. Every year, millions of animals are used for experimental testing during which these suffer from pain and are then eventually sacrificed. Besides bioethical issues, animal experimentation is associated with many disadvantages like high cost, the requirement of skilled manpower, approval, and is time-consuming. Therefore, attempts have been made by researchers to design and develop a number of alternative methods that could bypass animal experiments. These methods not only give accurate results but can also save lives of millions of animals annually. Research techniques, including computer and robotics together with molecular biology techniques, are applied to discover new methods to replace animal testing. Several alternative methods are discussed in this review. Some of these methods can predict the behavior of drugs accurately and are as reliable as in-vivo animal models. Furthermore, these alternative methods offer a variety of advantages over experimental animals. However, there is still a great need to discover and develop new, accurate, and reliable methods to replace experimental animals. |
| first_indexed | 2024-04-24T13:19:23Z |
| format | Article |
| id | doaj.art-64d3a8c4b4d74b91b53bb700fa0646b7 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-04-24T13:19:23Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-64d3a8c4b4d74b91b53bb700fa0646b72024-04-04T16:37:03ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062023-01-0115416517110.4103/jpbs.jpbs_380_23A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategiesAsif HusainDhanalekshmi U MeenakshiAftab AhmadNeelima ShrivastavaShah A KhanWith an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise. Every year, millions of animals are used for experimental testing during which these suffer from pain and are then eventually sacrificed. Besides bioethical issues, animal experimentation is associated with many disadvantages like high cost, the requirement of skilled manpower, approval, and is time-consuming. Therefore, attempts have been made by researchers to design and develop a number of alternative methods that could bypass animal experiments. These methods not only give accurate results but can also save lives of millions of animals annually. Research techniques, including computer and robotics together with molecular biology techniques, are applied to discover new methods to replace animal testing. Several alternative methods are discussed in this review. Some of these methods can predict the behavior of drugs accurately and are as reliable as in-vivo animal models. Furthermore, these alternative methods offer a variety of advantages over experimental animals. However, there is still a great need to discover and develop new, accurate, and reliable methods to replace experimental animals.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=4;spage=165;epage=171;aulast=Husainalternative organismscell culturerefinementreplacementvertebrate |
| spellingShingle | Asif Husain Dhanalekshmi U Meenakshi Aftab Ahmad Neelima Shrivastava Shah A Khan A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies Journal of Pharmacy and Bioallied Sciences alternative organisms cell culture refinement replacement vertebrate |
| title | A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies |
| title_full | A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies |
| title_fullStr | A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies |
| title_full_unstemmed | A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies |
| title_short | A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies |
| title_sort | review on alternative methods to experimental animals in biological testing recent advancement and current strategies |
| topic | alternative organisms cell culture refinement replacement vertebrate |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=4;spage=165;epage=171;aulast=Husain |
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