WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity
Adipocyte dysregulation is one mechanism linking overweight and breast cancer recurrence. Exercise and weight loss are associated with a decreased risk of breast cancer recurrence in breast cancer survivors with overweight or obesity, which may be mediated through reduced leptin levels, increased ad...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3453 |
| _version_ | 1797586161396350976 |
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| author | Dan Lin Kathleen M. Sturgeon Brett R. Gordon Justin C. Brown Dorothy D. Sears David B. Sarwer Kathryn H. Schmitz |
| author_facet | Dan Lin Kathleen M. Sturgeon Brett R. Gordon Justin C. Brown Dorothy D. Sears David B. Sarwer Kathryn H. Schmitz |
| author_sort | Dan Lin |
| collection | DOAJ |
| description | Adipocyte dysregulation is one mechanism linking overweight and breast cancer recurrence. Exercise and weight loss are associated with a decreased risk of breast cancer recurrence in breast cancer survivors with overweight or obesity, which may be mediated through reduced leptin levels, increased adiponectin levels, and an elevated adiponectin to leptin (A:L) ratio. The four-arm randomized controlled WISER Survivor trial examined the 12-month intervention effects of exercise, weight loss, and the combination of exercise and weight loss on adipokine levels among breast cancer survivors (<i>n</i> = 339) with overweight or obesity. Compared with Control, the Combination of Exercise and Weight Loss decreased leptin levels (−35.9%; 95% CI: −46.8%, −25.0%) and increased A:L ratio (11.6%; 95% CI: 5.6%, 17.6%) but did not change adiponectin levels (4.1%; 95% CI: −3.1%, 11.2%). Compared with Control, Weight Loss Alone decreased leptin levels (−35.6%; 95% CI: −46.6%, −24.5%) and increased A:L ratio (10.6%; 95% CI: 4.7%, 16.5%) but did not change adiponectin levels (0.9%; 95% CI: −6.0%, 7.9%). Compared with Control, Exercise Alone did not change leptin levels, adiponectin levels, or A:L ratio. In analyses that consolidated intervention groups, compared with Control, weight loss of ≥5% decreased leptin levels (<i>p</i> trend < 0.01) and increased A:L ratio (<i>p</i> trend < 0.01) but did not alter adiponectin levels (<i>p</i> trend = 0.53). Weight loss, with or without exercise, was associated with decreased leptin levels in breast cancer survivors with overweight or obesity. Improvements in the adipokine secretion profile (A:L ratio) were primarily driven by a weight loss-induced change in leptin levels. |
| first_indexed | 2024-03-11T00:19:31Z |
| format | Article |
| id | doaj.art-64d3edb822a74ee18d431e45150f0158 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:31Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-64d3edb822a74ee18d431e45150f01582023-11-18T23:24:46ZengMDPI AGNutrients2072-66432023-08-011515345310.3390/nu15153453WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or ObesityDan Lin0Kathleen M. Sturgeon1Brett R. Gordon2Justin C. Brown3Dorothy D. Sears4David B. Sarwer5Kathryn H. Schmitz6Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USACancer Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USACollege of Public Health, Center for Obesity Research and Education, Temple University, Philadelphia, PA 19122, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USAAdipocyte dysregulation is one mechanism linking overweight and breast cancer recurrence. Exercise and weight loss are associated with a decreased risk of breast cancer recurrence in breast cancer survivors with overweight or obesity, which may be mediated through reduced leptin levels, increased adiponectin levels, and an elevated adiponectin to leptin (A:L) ratio. The four-arm randomized controlled WISER Survivor trial examined the 12-month intervention effects of exercise, weight loss, and the combination of exercise and weight loss on adipokine levels among breast cancer survivors (<i>n</i> = 339) with overweight or obesity. Compared with Control, the Combination of Exercise and Weight Loss decreased leptin levels (−35.9%; 95% CI: −46.8%, −25.0%) and increased A:L ratio (11.6%; 95% CI: 5.6%, 17.6%) but did not change adiponectin levels (4.1%; 95% CI: −3.1%, 11.2%). Compared with Control, Weight Loss Alone decreased leptin levels (−35.6%; 95% CI: −46.6%, −24.5%) and increased A:L ratio (10.6%; 95% CI: 4.7%, 16.5%) but did not change adiponectin levels (0.9%; 95% CI: −6.0%, 7.9%). Compared with Control, Exercise Alone did not change leptin levels, adiponectin levels, or A:L ratio. In analyses that consolidated intervention groups, compared with Control, weight loss of ≥5% decreased leptin levels (<i>p</i> trend < 0.01) and increased A:L ratio (<i>p</i> trend < 0.01) but did not alter adiponectin levels (<i>p</i> trend = 0.53). Weight loss, with or without exercise, was associated with decreased leptin levels in breast cancer survivors with overweight or obesity. Improvements in the adipokine secretion profile (A:L ratio) were primarily driven by a weight loss-induced change in leptin levels.https://www.mdpi.com/2072-6643/15/15/3453breast neoplasmsobesityexerciseweight lossadipokines |
| spellingShingle | Dan Lin Kathleen M. Sturgeon Brett R. Gordon Justin C. Brown Dorothy D. Sears David B. Sarwer Kathryn H. Schmitz WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity Nutrients breast neoplasms obesity exercise weight loss adipokines |
| title | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity |
| title_full | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity |
| title_fullStr | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity |
| title_full_unstemmed | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity |
| title_short | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity |
| title_sort | wiser survivor trial combined effect of exercise and weight loss interventions on adiponectin and leptin levels in breast cancer survivors with overweight or obesity |
| topic | breast neoplasms obesity exercise weight loss adipokines |
| url | https://www.mdpi.com/2072-6643/15/15/3453 |
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