2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-5-one

2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-5-one

The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1...

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Bibliographic Details
Main Authors:	Perla Islas-Jácome, Cecilia García-Falcón, Sandra L. Castañón-Alonso, Ernesto Calderón-Jaimes, Daniel Canseco-González, Alejandro Islas-Jácome, Eduardo González-Zamora
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	Molbank
Subjects:	multicomponent reactions (MCRs) Ugi-Zhu reaction (UZ-3CR) polyheterocycles pyrrolo[3,4-<i>b</i>]pyridin-5-ones 1<i>H</i>-1,2,3-triazoles
Online Access:	https://www.mdpi.com/1422-8599/2023/3/M1693

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Summary:	The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methanamine, 2-isocyano-1-morpholino-3-phenylpropan-1-one, and maleic anhydride under a microwave-assisted one-pot process [Ugi-Zhu/aza Diels-Alder cycloaddition/<i>N</i>-acylation/decarboxylation/dehydration] with a 28% overall yield. The synthesized compound was fully characterized by 1D (<sup>1</sup>H, <sup>13</sup>C) and 2D (COSY, HSQC, and HMBC) NMR, FT-IR, and HRMS.
ISSN:	1422-8599