An estriol-eluting pessary to treat pelvic organ prolapse
Abstract Pelvic organ prolapse affects up to 50% of parous women. Commonly used treatment options have unwelcome attributes; pessaries can cause erosion and estrogen creams need to be applied frequently, which is inconvenient and difficult to administer. This study involved the development of an est...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23791-9 |
| _version_ | 1811210967438065664 |
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| author | Jingjunjiao Long Ghada Zidan Ali Seyfoddin Stephen Tong Fiona C. Brownfoot Prathima Chowdary |
| author_facet | Jingjunjiao Long Ghada Zidan Ali Seyfoddin Stephen Tong Fiona C. Brownfoot Prathima Chowdary |
| author_sort | Jingjunjiao Long |
| collection | DOAJ |
| description | Abstract Pelvic organ prolapse affects up to 50% of parous women. Commonly used treatment options have unwelcome attributes; pessaries can cause erosion and estrogen creams need to be applied frequently, which is inconvenient and difficult to administer. This study involved the development of an estriol-releasing pessary utilising 3D printing molds. We incorporated varying amounts of estriol (1%, 10% and 15%) into the silicone pessary. We optimised the mechanical aspects of the pessary so it had a similar strength to commercially available pessaries. We investigated estriol release from the pessary over 3 months. We explored possible interactions between the drug and polymers via FTIR. The MED-4870 silicone ring with similar mechanical strength to pessaries currently used to treat pelvic organ prolapse. The medical pessaries present a sustained release in simulated vaginal fluid over 3 months. The pessary with 10% estriol delivered the optimal dose at 0.8 mg each week. Mechanical strength of this pessary showed no difference after emersion in simulated vaginal fluid for 3-month, supporting the long-term application. An estriol-loaded pessary was successfully developed to treat pelvic organ prolapse with sustained release of estriol over 3 months. This pessary provides promising potential to treat pelvic organ prolapse and vaginal atrophy. |
| first_indexed | 2024-04-12T05:04:53Z |
| format | Article |
| id | doaj.art-64d499f02d434669b496ae0fdcb90bf6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T05:04:53Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-64d499f02d434669b496ae0fdcb90bf62022-12-22T03:46:54ZengNature PortfolioScientific Reports2045-23222022-11-0112111110.1038/s41598-022-23791-9An estriol-eluting pessary to treat pelvic organ prolapseJingjunjiao Long0Ghada Zidan1Ali Seyfoddin2Stephen Tong3Fiona C. Brownfoot4Prathima Chowdary5Drug Delivery Research Group, Faculty of Health and Environmental Sciences, School of Science, Auckland University of TechnologyDrug Delivery Research Group, Faculty of Health and Environmental Sciences, School of Science, Auckland University of TechnologyDrug Delivery Research Group, Faculty of Health and Environmental Sciences, School of Science, Auckland University of TechnologyTranslational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for WomenObstetric Diagnostics and Therapeutics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for WomenDepartment of Obstetrics and Gynaecology, University of AucklandAbstract Pelvic organ prolapse affects up to 50% of parous women. Commonly used treatment options have unwelcome attributes; pessaries can cause erosion and estrogen creams need to be applied frequently, which is inconvenient and difficult to administer. This study involved the development of an estriol-releasing pessary utilising 3D printing molds. We incorporated varying amounts of estriol (1%, 10% and 15%) into the silicone pessary. We optimised the mechanical aspects of the pessary so it had a similar strength to commercially available pessaries. We investigated estriol release from the pessary over 3 months. We explored possible interactions between the drug and polymers via FTIR. The MED-4870 silicone ring with similar mechanical strength to pessaries currently used to treat pelvic organ prolapse. The medical pessaries present a sustained release in simulated vaginal fluid over 3 months. The pessary with 10% estriol delivered the optimal dose at 0.8 mg each week. Mechanical strength of this pessary showed no difference after emersion in simulated vaginal fluid for 3-month, supporting the long-term application. An estriol-loaded pessary was successfully developed to treat pelvic organ prolapse with sustained release of estriol over 3 months. This pessary provides promising potential to treat pelvic organ prolapse and vaginal atrophy.https://doi.org/10.1038/s41598-022-23791-9 |
| spellingShingle | Jingjunjiao Long Ghada Zidan Ali Seyfoddin Stephen Tong Fiona C. Brownfoot Prathima Chowdary An estriol-eluting pessary to treat pelvic organ prolapse Scientific Reports |
| title | An estriol-eluting pessary to treat pelvic organ prolapse |
| title_full | An estriol-eluting pessary to treat pelvic organ prolapse |
| title_fullStr | An estriol-eluting pessary to treat pelvic organ prolapse |
| title_full_unstemmed | An estriol-eluting pessary to treat pelvic organ prolapse |
| title_short | An estriol-eluting pessary to treat pelvic organ prolapse |
| title_sort | estriol eluting pessary to treat pelvic organ prolapse |
| url | https://doi.org/10.1038/s41598-022-23791-9 |
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