Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance
Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mecha...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.976385/full |
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| author | Md. Mominur Rahman Xiaoyan Wang Md. Rezaul Islam Shopnil Akash Fatema Akter Supti Mohona Islam Mitu Md. Harun-Or-Rashid Most. Nazmin Aktar Most. Sumaiya Khatun Kali Farhana Israt Jahan Rajeev K. Singla Rajeev K. Singla Bairong Shen Abdur Rauf Rohit Sharma |
| author_facet | Md. Mominur Rahman Xiaoyan Wang Md. Rezaul Islam Shopnil Akash Fatema Akter Supti Mohona Islam Mitu Md. Harun-Or-Rashid Most. Nazmin Aktar Most. Sumaiya Khatun Kali Farhana Israt Jahan Rajeev K. Singla Rajeev K. Singla Bairong Shen Abdur Rauf Rohit Sharma |
| author_sort | Md. Mominur Rahman |
| collection | DOAJ |
| description | Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson’s and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD. |
| first_indexed | 2024-04-12T00:39:31Z |
| format | Article |
| id | doaj.art-64da829fb5434fd3b458ccbecf38827b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T00:39:31Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-64da829fb5434fd3b458ccbecf38827b2022-12-22T03:55:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.976385976385Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glanceMd. Mominur Rahman0Xiaoyan Wang1Md. Rezaul Islam2Shopnil Akash3Fatema Akter Supti4Mohona Islam Mitu5Md. Harun-Or-Rashid6Most. Nazmin Aktar7Most. Sumaiya Khatun Kali8Farhana Israt Jahan9Rajeev K. Singla10Rajeev K. Singla11Bairong Shen12Abdur Rauf13Rohit Sharma14Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pathology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, BangladeshInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, IndiaInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Chemistry, University of Swabi, Swabi, PakistanDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaNatural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson’s and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD.https://www.frontiersin.org/articles/10.3389/fphar.2022.976385/fullParkinson’s diseasemedicinal plantsnatural productstreatmentneurodegenerationneuroinflammation |
| spellingShingle | Md. Mominur Rahman Xiaoyan Wang Md. Rezaul Islam Shopnil Akash Fatema Akter Supti Mohona Islam Mitu Md. Harun-Or-Rashid Most. Nazmin Aktar Most. Sumaiya Khatun Kali Farhana Israt Jahan Rajeev K. Singla Rajeev K. Singla Bairong Shen Abdur Rauf Rohit Sharma Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance Frontiers in Pharmacology Parkinson’s disease medicinal plants natural products treatment neurodegeneration neuroinflammation |
| title | Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance |
| title_full | Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance |
| title_fullStr | Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance |
| title_full_unstemmed | Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance |
| title_short | Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance |
| title_sort | multifunctional role of natural products for the treatment of parkinson s disease at a glance |
| topic | Parkinson’s disease medicinal plants natural products treatment neurodegeneration neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.976385/full |
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