Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study

Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study

Abstract Background Plasma hyaluronan concentrations are increased during sepsis but underlying mechanisms leading to high plasma hyaluronan concentration are poorly understood. In this study we evaluate the roles of plasma hyaluronan, effective plasma hyaluronidase (HYAL) activity and its endogenou...

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Bibliographic Details
Main Authors: Jaap van der Heijden, Constantinos Kolliopoulos, Paul Skorup, Marko Sallisalmi, Paraskevi Heldin, Michael Hultström, Jyrki Tenhunen
Format: Article
Language:English
Published: SpringerOpen 2021-10-01
Series:Intensive Care Medicine Experimental
Subjects:
Hyaluronan
Hyaluronidase
Hyaluronidase inhibitor
Sepsis
Pancreatitis
Glycocalyx
Online Access:https://doi.org/10.1186/s40635-021-00418-3

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