Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives
Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides—cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/21/3918 |
| _version_ | 1819158493481926656 |
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| author | Joana F. Malheiro Jean-Yves Maillard Fernanda Borges Manuel Simões |
| author_facet | Joana F. Malheiro Jean-Yves Maillard Fernanda Borges Manuel Simões |
| author_sort | Joana F. Malheiro |
| collection | DOAJ |
| description | Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides—cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, α-methylcinnamic, and α-fluorocinnamic acids had a factional inhibitory concentration index (FICI) ≤ 1 for <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Several phytochemicals/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacteria. The most effective combination was LA with allyl cinnamate (2.98 ± 0.76 log CFU·cm<sup>−2</sup> reduction) against <i>E. coli</i>. The combination with CTAB was successful for most phytochemicals/derivatives with a maximum bactericidal efficacy against sessile <i>E. coli</i> when combined with allyl cinnamate (2.20 ± 0.07 log CFU·cm<sup>−2</sup> reduction) and for <i>S. aureus</i> when combined with α-methylcinnamic acid (1.68 ± 0.30 log CFU·cm<sup>−2</sup> reduction). This study highlights the potential of phytochemicals and their derivatives to be used in biocide formulations. |
| first_indexed | 2024-12-22T16:25:32Z |
| format | Article |
| id | doaj.art-64db32631a264bd5803b83c147a41686 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T16:25:32Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-64db32631a264bd5803b83c147a416862022-12-21T18:20:10ZengMDPI AGMolecules1420-30492019-10-012421391810.3390/molecules24213918molecules24213918Biocide Potentiation Using Cinnamic Phytochemicals and DerivativesJoana F. Malheiro0Jean-Yves Maillard1Fernanda Borges2Manuel Simões3LEPABE, Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, PortugalCardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales CF10 3NB, UKCIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences University of Porto, Rua do Campo Alegre, 4169-007 Porto, PortugalLEPABE, Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, PortugalSurface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides—cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, α-methylcinnamic, and α-fluorocinnamic acids had a factional inhibitory concentration index (FICI) ≤ 1 for <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Several phytochemicals/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacteria. The most effective combination was LA with allyl cinnamate (2.98 ± 0.76 log CFU·cm<sup>−2</sup> reduction) against <i>E. coli</i>. The combination with CTAB was successful for most phytochemicals/derivatives with a maximum bactericidal efficacy against sessile <i>E. coli</i> when combined with allyl cinnamate (2.20 ± 0.07 log CFU·cm<sup>−2</sup> reduction) and for <i>S. aureus</i> when combined with α-methylcinnamic acid (1.68 ± 0.30 log CFU·cm<sup>−2</sup> reduction). This study highlights the potential of phytochemicals and their derivatives to be used in biocide formulations.https://www.mdpi.com/1420-3049/24/21/3918biocidedisinfectionphytochemicalspotentiationsessile cells |
| spellingShingle | Joana F. Malheiro Jean-Yves Maillard Fernanda Borges Manuel Simões Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives Molecules biocide disinfection phytochemicals potentiation sessile cells |
| title | Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives |
| title_full | Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives |
| title_fullStr | Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives |
| title_full_unstemmed | Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives |
| title_short | Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives |
| title_sort | biocide potentiation using cinnamic phytochemicals and derivatives |
| topic | biocide disinfection phytochemicals potentiation sessile cells |
| url | https://www.mdpi.com/1420-3049/24/21/3918 |
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