HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers
Background The aim of this study was to evaluate the association between CYP2A13 polymorphisms and lung cancer susceptibility using the HapMap database. Methods A case‐control analysis of 532 subjects with lung cancer and 614 controls with no personal history of the disease was performed. The tag SN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-04-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.12954 |
| _version_ | 1797845470781898752 |
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| author | Feng Hua Yonglu Guo Qiang Sun Leizhou Yang Fang Gao |
| author_facet | Feng Hua Yonglu Guo Qiang Sun Leizhou Yang Fang Gao |
| author_sort | Feng Hua |
| collection | DOAJ |
| description | Background The aim of this study was to evaluate the association between CYP2A13 polymorphisms and lung cancer susceptibility using the HapMap database. Methods A case‐control analysis of 532 subjects with lung cancer and 614 controls with no personal history of the disease was performed. The tag SNPs rs1645690 and rs8192789 for CYP2A13 were selected, and the genetic polymorphisms were confirmed experimentally through real‐time PCR, cloning, and sequencing assay. Results SNP frequency in this study was consistent with the HapMap Project database of Han‐Chinese and lung cancer risk was associated with CYP2A13 polymorphisms in non‐smokers. CYP2A13 shares a 93.5% identity with CYP2A6 in the amino acid sequence and the homologous sequences may interfere with the study of SNPs of CYP2A13. Conclusions CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers. The common polymorphisms of CYP2A13 may be candidate biomarkers for lung cancer susceptibility in Han‐Chinese. |
| first_indexed | 2024-04-09T17:39:33Z |
| format | Article |
| id | doaj.art-64db77c7aa634a78956578d6016c775c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-09T17:39:33Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-64db77c7aa634a78956578d6016c775c2023-04-17T06:34:27ZengWileyThoracic Cancer1759-77061759-77142019-04-0110460160610.1111/1759-7714.12954HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokersFeng Hua0Yonglu Guo1Qiang Sun2Leizhou Yang3Fang Gao4Department of Thoracic Surgery Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences Jinan ChinaDepartment of Respiratory Jiuquan City People's Hospital Jiuquan ChinaDepartment of Infection Jiuquan City People's Hospital Jiuquan ChinaDepartment of Internal Medicine Jining City Yanzhou District Railway Hospital Jining ChinaDepartment of Thoracic Surgery Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences Jinan ChinaBackground The aim of this study was to evaluate the association between CYP2A13 polymorphisms and lung cancer susceptibility using the HapMap database. Methods A case‐control analysis of 532 subjects with lung cancer and 614 controls with no personal history of the disease was performed. The tag SNPs rs1645690 and rs8192789 for CYP2A13 were selected, and the genetic polymorphisms were confirmed experimentally through real‐time PCR, cloning, and sequencing assay. Results SNP frequency in this study was consistent with the HapMap Project database of Han‐Chinese and lung cancer risk was associated with CYP2A13 polymorphisms in non‐smokers. CYP2A13 shares a 93.5% identity with CYP2A6 in the amino acid sequence and the homologous sequences may interfere with the study of SNPs of CYP2A13. Conclusions CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers. The common polymorphisms of CYP2A13 may be candidate biomarkers for lung cancer susceptibility in Han‐Chinese.https://doi.org/10.1111/1759-7714.12954CYP2A13genetic polymorphismHapMap Projectlung cancersusceptibility |
| spellingShingle | Feng Hua Yonglu Guo Qiang Sun Leizhou Yang Fang Gao HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers Thoracic Cancer CYP2A13 genetic polymorphism HapMap Project lung cancer susceptibility |
| title | HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers |
| title_full | HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers |
| title_fullStr | HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers |
| title_full_unstemmed | HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers |
| title_short | HapMap‐based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non‐smokers |
| title_sort | hapmap based study cyp2a13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non smokers |
| topic | CYP2A13 genetic polymorphism HapMap Project lung cancer susceptibility |
| url | https://doi.org/10.1111/1759-7714.12954 |
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