Conjunctival lymphoma arising from reactive lymphoid hyperplasia
<p>Abstract</p> <p>Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lympho...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/194 |
| _version_ | 1819029062041993216 |
|---|---|
| author | Fukuhara Junichi Kase Satoru Noda Mika Ishijima Kan Yamamoto Teppei Ishida Susumu |
| author_facet | Fukuhara Junichi Kase Satoru Noda Mika Ishijima Kan Yamamoto Teppei Ishida Susumu |
| author_sort | Fukuhara Junichi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig) light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS), and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH) region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.</p> |
| first_indexed | 2024-12-21T06:08:17Z |
| format | Article |
| id | doaj.art-64dd2161446143bfa57b43676b54e0a2 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-21T06:08:17Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-64dd2161446143bfa57b43676b54e0a22022-12-21T19:13:35ZengBMCWorld Journal of Surgical Oncology1477-78192012-09-0110119410.1186/1477-7819-10-194Conjunctival lymphoma arising from reactive lymphoid hyperplasiaFukuhara JunichiKase SatoruNoda MikaIshijima KanYamamoto TeppeiIshida Susumu<p>Abstract</p> <p>Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig) light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS), and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH) region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.</p>http://www.wjso.com/content/10/1/194ConjunctivaExtra nodal marginal zone B-cell lymphomaReactive lymphoid hyperplasia |
| spellingShingle | Fukuhara Junichi Kase Satoru Noda Mika Ishijima Kan Yamamoto Teppei Ishida Susumu Conjunctival lymphoma arising from reactive lymphoid hyperplasia World Journal of Surgical Oncology Conjunctiva Extra nodal marginal zone B-cell lymphoma Reactive lymphoid hyperplasia |
| title | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| title_full | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| title_fullStr | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| title_full_unstemmed | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| title_short | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| title_sort | conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| topic | Conjunctiva Extra nodal marginal zone B-cell lymphoma Reactive lymphoid hyperplasia |
| url | http://www.wjso.com/content/10/1/194 |
| work_keys_str_mv | AT fukuharajunichi conjunctivallymphomaarisingfromreactivelymphoidhyperplasia AT kasesatoru conjunctivallymphomaarisingfromreactivelymphoidhyperplasia AT nodamika conjunctivallymphomaarisingfromreactivelymphoidhyperplasia AT ishijimakan conjunctivallymphomaarisingfromreactivelymphoidhyperplasia AT yamamototeppei conjunctivallymphomaarisingfromreactivelymphoidhyperplasia AT ishidasusumu conjunctivallymphomaarisingfromreactivelymphoidhyperplasia |