Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble.

Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble.

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-called astrocyte-neuron lactate shuttle (ANLS) ar...

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Bibliographic Details
Main Authors: Renaud Jolivet, Jay S Coggan, Igor Allaman, Pierre J Magistretti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004036&type=printable

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