INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidad de Antioquia
2009-02-01
|
| Series: | Vitae |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/802 |
| Summary: | Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural
component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as
a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic
leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian
marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y
Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most
of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament
used against cancer which is used as a control for the bioassays. Results demonstrate that some of the
analyzed extracts have more inhibition than the control metotrexate®. |
|---|---|
| ISSN: | 0121-4004 2145-2660 |