INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like...
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| Format: | Article |
| Language: | English |
| Published: |
Universidad de Antioquia
2009-02-01
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| Series: | Vitae |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/802 |
| _version_ | 1818370072101519360 |
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| author | Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ |
| author_facet | Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ |
| author_sort | Diego A. ZABALA |
| collection | DOAJ |
| description | Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural
component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as
a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic
leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian
marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y
Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most
of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament
used against cancer which is used as a control for the bioassays. Results demonstrate that some of the
analyzed extracts have more inhibition than the control metotrexate®. |
| first_indexed | 2024-12-13T23:33:55Z |
| format | Article |
| id | doaj.art-64df11181edc41b4aa519ca95db4d5b6 |
| institution | Directory Open Access Journal |
| issn | 0121-4004 2145-2660 |
| language | English |
| last_indexed | 2024-12-13T23:33:55Z |
| publishDate | 2009-02-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Vitae |
| spelling | doaj.art-64df11181edc41b4aa519ca95db4d5b62022-12-21T23:27:21ZengUniversidad de AntioquiaVitae0121-40042145-26602009-02-01152INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYMEDiego A. ZABALABibiana ECAVARRÍAAlejandro MARTÍNEZDihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament used against cancer which is used as a control for the bioassays. Results demonstrate that some of the analyzed extracts have more inhibition than the control metotrexate®.https://revistas.udea.edu.co/index.php/vitae/article/view/802Dihydrofolate reductasemetotrexate®marine sponges. |
| spellingShingle | Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME Vitae Dihydrofolate reductase metotrexate® marine sponges. |
| title | INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME |
| title_full | INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME |
| title_fullStr | INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME |
| title_full_unstemmed | INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME |
| title_short | INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME |
| title_sort | inhibitory activity of some marine sponge extracts from uraba gulf on dihydrofolate reductase enzyme |
| topic | Dihydrofolate reductase metotrexate® marine sponges. |
| url | https://revistas.udea.edu.co/index.php/vitae/article/view/802 |
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