Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity
The increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over differ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00051/full |
| _version_ | 1818914302654939136 |
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| author | Aysooda Hosseinzade Omid Sadeghi Omid Sadeghi Akram Naghdipour Biregani Sepideh Soukhtehzari Gabriel S. Brandt Ahmad Esmaillzadeh Ahmad Esmaillzadeh Ahmad Esmaillzadeh |
| author_facet | Aysooda Hosseinzade Omid Sadeghi Omid Sadeghi Akram Naghdipour Biregani Sepideh Soukhtehzari Gabriel S. Brandt Ahmad Esmaillzadeh Ahmad Esmaillzadeh Ahmad Esmaillzadeh |
| author_sort | Aysooda Hosseinzade |
| collection | DOAJ |
| description | The increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over different types of immune cells, T lymphocytes play a critical role in protecting the immune system as well as in the pathogenesis of specific autoimmune diseases. One of the important mediators of metabolism and immune system is mTOR, especially in T lymphocytes. In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway. Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset. |
| first_indexed | 2024-12-19T23:44:14Z |
| format | Article |
| id | doaj.art-64e035e0b8bb45a5a742d6707bf36485 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T23:44:14Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-64e035e0b8bb45a5a742d6707bf364852022-12-21T20:01:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-01-011010.3389/fimmu.2019.00051412793Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling ActivityAysooda Hosseinzade0Omid Sadeghi1Omid Sadeghi2Akram Naghdipour Biregani3Sepideh Soukhtehzari4Gabriel S. Brandt5Ahmad Esmaillzadeh6Ahmad Esmaillzadeh7Ahmad Esmaillzadeh8Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Pharmaceutical Science, University of British Columbia, Vancouver, BC, CanadaDepartment of Chemistry, Franklin & Marshall College,, Lancaster, PA, United StatesStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranObesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranThe increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over different types of immune cells, T lymphocytes play a critical role in protecting the immune system as well as in the pathogenesis of specific autoimmune diseases. One of the important mediators of metabolism and immune system is mTOR, especially in T lymphocytes. In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway. Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset.https://www.frontiersin.org/article/10.3389/fimmu.2019.00051/fullflavonoidsmTORautoimmunitymetabolismT regulatory cells |
| spellingShingle | Aysooda Hosseinzade Omid Sadeghi Omid Sadeghi Akram Naghdipour Biregani Sepideh Soukhtehzari Gabriel S. Brandt Ahmad Esmaillzadeh Ahmad Esmaillzadeh Ahmad Esmaillzadeh Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity Frontiers in Immunology flavonoids mTOR autoimmunity metabolism T regulatory cells |
| title | Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity |
| title_full | Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity |
| title_fullStr | Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity |
| title_full_unstemmed | Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity |
| title_short | Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity |
| title_sort | immunomodulatory effects of flavonoids possible induction of t cd4 regulatory cells through suppression of mtor pathway signaling activity |
| topic | flavonoids mTOR autoimmunity metabolism T regulatory cells |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00051/full |
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