Folate and Cancer
Folate plays a central role in DNA synthesis and methylation, which are essential for DNA integrity maintenance and gene expression. Folate deficiency may lead to the incorporation of uracil into DNA and chromosome breaks, increasing the risk of cancer. However, conflicting evidence has been observe...
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| Format: | Article |
| Language: | English |
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SciELO
2016-07-01
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| Series: | Journal of Inborn Errors of Metabolism and Screening |
| Online Access: | https://doi.org/10.1177/2326409816661357 |
| _version_ | 1811246658396094464 |
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| author | Luciana Yuki Tomita PhD |
| author_facet | Luciana Yuki Tomita PhD |
| author_sort | Luciana Yuki Tomita PhD |
| collection | DOAJ |
| description | Folate plays a central role in DNA synthesis and methylation, which are essential for DNA integrity maintenance and gene expression. Folate deficiency may lead to the incorporation of uracil into DNA and chromosome breaks, increasing the risk of cancer. However, conflicting evidence has been observed depending on the type of epidemiological study, dietary or circulating folate, and the type of cancer. New concern has arisen after a mandatory folic acid (FA) fortification program adopted for the prevention of neural tube defects in the United States, which suggested an increase in the incidence of colorectal cancer. In the present article, folate status and cancer are under review, and a discussion of the challenge of assessing folate status through food intake, supplement use, FA fortification programs, circulating folate, and the interaction of diet and the polymorphism of the enzyme involved in folate metabolism will be presented. |
| first_indexed | 2024-04-12T14:56:04Z |
| format | Article |
| id | doaj.art-64e0aac9c6b54dafb98348b5efb5e18c |
| institution | Directory Open Access Journal |
| issn | 2326-4594 |
| language | English |
| last_indexed | 2024-04-12T14:56:04Z |
| publishDate | 2016-07-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Inborn Errors of Metabolism and Screening |
| spelling | doaj.art-64e0aac9c6b54dafb98348b5efb5e18c2022-12-22T03:28:13ZengSciELOJournal of Inborn Errors of Metabolism and Screening2326-45942016-07-01410.1177/232640981666135710.1177_2326409816661357Folate and CancerLuciana Yuki Tomita PhD0 Department of Preventive Medicine, Federal University of São Paulo, São Paulo, BrazilFolate plays a central role in DNA synthesis and methylation, which are essential for DNA integrity maintenance and gene expression. Folate deficiency may lead to the incorporation of uracil into DNA and chromosome breaks, increasing the risk of cancer. However, conflicting evidence has been observed depending on the type of epidemiological study, dietary or circulating folate, and the type of cancer. New concern has arisen after a mandatory folic acid (FA) fortification program adopted for the prevention of neural tube defects in the United States, which suggested an increase in the incidence of colorectal cancer. In the present article, folate status and cancer are under review, and a discussion of the challenge of assessing folate status through food intake, supplement use, FA fortification programs, circulating folate, and the interaction of diet and the polymorphism of the enzyme involved in folate metabolism will be presented.https://doi.org/10.1177/2326409816661357 |
| spellingShingle | Luciana Yuki Tomita PhD Folate and Cancer Journal of Inborn Errors of Metabolism and Screening |
| title | Folate and Cancer |
| title_full | Folate and Cancer |
| title_fullStr | Folate and Cancer |
| title_full_unstemmed | Folate and Cancer |
| title_short | Folate and Cancer |
| title_sort | folate and cancer |
| url | https://doi.org/10.1177/2326409816661357 |
| work_keys_str_mv | AT lucianayukitomitaphd folateandcancer |