Diagnostic performance of hematological indices in early and late preeclampsia
To evaluate diagnostic performance of Neutrophil/lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR) and platelecrit in the first and third trimester in preeclampsia. This was a single center case control study conducted between January 2015 and January 2021. Patients diagnosed with preeclamp...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2022-03-01
|
| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=135987 |
| _version_ | 1797328177844977664 |
|---|---|
| author | Dicle Iskender Mehmet Obut Ayse Keles Ozgur Arat Ozge Yucel Celik Dilara Sarikaya Mehmet Kaya Mehmet Sinan Dal Can Tekin Iskender |
| author_facet | Dicle Iskender Mehmet Obut Ayse Keles Ozgur Arat Ozge Yucel Celik Dilara Sarikaya Mehmet Kaya Mehmet Sinan Dal Can Tekin Iskender |
| author_sort | Dicle Iskender |
| collection | DOAJ |
| description | To evaluate diagnostic performance of Neutrophil/lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR) and platelecrit in the first and third trimester in preeclampsia. This was a single center case control study conducted between January 2015 and January 2021. Patients diagnosed with preeclampsia were assigned as study population. The preeclamptic patients were assigned into two groups based on gestational weeks at diagnosis. Patients diagnosed before 34th gestational weeks were categorized as early preeclampsia and whereas patients diagnosed after 34th gestational weeks as late preeclampsia. Receiver operating characteristics curve was used to assess diagnostic value of first and third trimester NLR, PLR and platelecrit in preeclampsia. Detection rate of each variable was assessed for a 10% false positive rate. NLR in the first trimester have highest sensitivity of 30 % at a 90 % specificity to detect early preeclampsia. The area under curve (AUC) for NLR was 0.742 respectively. The best cut off for 1st trimester NLR was 4.98. PLR and platelecrit yielded low diagnostic performance. NLR in the first trimester has a moderate predictive performance for early preeclampsia. PLR was not different in preeclamptic cases and controls and platelecrit yielded a low diagnostic performance for preeclampsia. [Med-Science 2022; 11(1.000): 148-53] |
| first_indexed | 2024-03-08T06:47:07Z |
| format | Article |
| id | doaj.art-64e0dd4892f146a486c284f1e22dae07 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:47:07Z |
| publishDate | 2022-03-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-64e0dd4892f146a486c284f1e22dae072024-02-03T07:29:09ZengSociety of Turaz BilimMedicine Science2147-06342022-03-011111485310.5455/medscience.2021.10.357135987Diagnostic performance of hematological indices in early and late preeclampsiaDicle Iskender0Mehmet Obut1Ayse Keles2Ozgur Arat3Ozge Yucel Celik4Dilara Sarikaya5Mehmet Kaya6Mehmet Sinan Dal7Can Tekin Iskender8Department of Hematology, Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Perinatology, Health Sciences University, Etlik Zubeyde Hanım Womans Health Training and Research Hospital, Ankara, Turkey Department of Hematology, Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey Department of Hematology, a Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, TurkeyTo evaluate diagnostic performance of Neutrophil/lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR) and platelecrit in the first and third trimester in preeclampsia. This was a single center case control study conducted between January 2015 and January 2021. Patients diagnosed with preeclampsia were assigned as study population. The preeclamptic patients were assigned into two groups based on gestational weeks at diagnosis. Patients diagnosed before 34th gestational weeks were categorized as early preeclampsia and whereas patients diagnosed after 34th gestational weeks as late preeclampsia. Receiver operating characteristics curve was used to assess diagnostic value of first and third trimester NLR, PLR and platelecrit in preeclampsia. Detection rate of each variable was assessed for a 10% false positive rate. NLR in the first trimester have highest sensitivity of 30 % at a 90 % specificity to detect early preeclampsia. The area under curve (AUC) for NLR was 0.742 respectively. The best cut off for 1st trimester NLR was 4.98. PLR and platelecrit yielded low diagnostic performance. NLR in the first trimester has a moderate predictive performance for early preeclampsia. PLR was not different in preeclamptic cases and controls and platelecrit yielded a low diagnostic performance for preeclampsia. [Med-Science 2022; 11(1.000): 148-53]http://www.ejmanager.com/fulltextpdf.php?mno=135987diagnostic performanceneutrophil to lymphocyte ratioplatelet to lymphocyte ratioplatelecritpreeclampsia |
| spellingShingle | Dicle Iskender Mehmet Obut Ayse Keles Ozgur Arat Ozge Yucel Celik Dilara Sarikaya Mehmet Kaya Mehmet Sinan Dal Can Tekin Iskender Diagnostic performance of hematological indices in early and late preeclampsia Medicine Science diagnostic performance neutrophil to lymphocyte ratio platelet to lymphocyte ratio platelecrit preeclampsia |
| title | Diagnostic performance of hematological indices in early and late preeclampsia |
| title_full | Diagnostic performance of hematological indices in early and late preeclampsia |
| title_fullStr | Diagnostic performance of hematological indices in early and late preeclampsia |
| title_full_unstemmed | Diagnostic performance of hematological indices in early and late preeclampsia |
| title_short | Diagnostic performance of hematological indices in early and late preeclampsia |
| title_sort | diagnostic performance of hematological indices in early and late preeclampsia |
| topic | diagnostic performance neutrophil to lymphocyte ratio platelet to lymphocyte ratio platelecrit preeclampsia |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=135987 |
| work_keys_str_mv | AT dicleiskender diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT mehmetobut diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT aysekeles diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT ozgurarat diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT ozgeyucelcelik diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT dilarasarikaya diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT mehmetkaya diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT mehmetsinandal diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia AT cantekiniskender diagnosticperformanceofhematologicalindicesinearlyandlatepreeclampsia |