MRI and MRS alterations in the preclinical phase of murine prion disease: Association with neuropathological and behavioural changes

MRI and MRS alterations in the preclinical phase of murine prion disease: Association with neuropathological and behavioural changes

Prion diseases are fatal chronic neurodegenerative diseases. Previous qualitative magnetic resonance imaging (MRI) and spectroscopy (MRS) studies report conflicting results in the symptomatic stages of the disease, but little work has been carried out during the earlier stages of the disease. Here w...

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Bibliographic Details
Main Authors: Kerry A. Broom, Daniel C. Anthony, John P. Lowe, Julian L. Griffin, Helen Scott, Andrew M. Blamire, Peter Styles, V. Hugh Perry, Nicola R. Sibson
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neurobiology of Disease
Subjects:
Magnetic resonance
Diffusion
N-acetyl aspartate
Prion
Chronic inflammation
Brain
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000794

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