Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience
Background. The use of faecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) has frequently failed to induce long-term symptomatic improvement. The use of multiple FMT infusions is one proposed mechanism through which the efficacy of FMT can be amplified. Aims. To evaluate the sa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/6083896 |
| _version_ | 1797990801942249472 |
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| author | Harrison Hamblin Anoja W. Gunaratne Annabel Clancy Denise Pilarinos Antoinette LeBusque Marie Vic M. Dawson Thomas J. Borody |
| author_facet | Harrison Hamblin Anoja W. Gunaratne Annabel Clancy Denise Pilarinos Antoinette LeBusque Marie Vic M. Dawson Thomas J. Borody |
| author_sort | Harrison Hamblin |
| collection | DOAJ |
| description | Background. The use of faecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) has frequently failed to induce long-term symptomatic improvement. The use of multiple FMT infusions is one proposed mechanism through which the efficacy of FMT can be amplified. Aims. To evaluate the safety and efficacy of a novel six-month FMT treatment protocol in IBS. Methods. Patients diagnosed with IBS confirmed by Rome IV Criteria were recruited for single-centre, single-arm, prospective clinical observational study. Participants received one colonoscopically delivered FMT followed by 36 rectal enemas across a six-month period. Validated abdominal symptoms and Short-Form (SF-36) Quality of Life (QOL) questionnaires were collected at baseline, week-12, week-24, and week-56, respectively. Wilcoxon matched-pairs signed-rank tests were conducted to compare differences in abdominal symptom and SF-36 QOL scores over the follow-up timepoints. Statistical significance was set at 5%. Results. Sixty participants diagnosed with IBS [IBS-constipation (n=27), IBS-diarrhoea (n=18), and IBS-mixed (n=15)] received the six-month FMT treatment. IBS symptom severity reduction was achieved in up to 61% of respondents at week-12, 64% of respondents at week-24, and maintained in up to 75% of respondents at week-52. Long-term reduction in symptom severity was associated with an increase in QOL, achieved in up to 64% of respondents at week-52 when compared to baseline. Adverse events were experienced in 28% of participants, though they were both transient and mild in nature. Conclusions. Six-month sustained FMT appears to be both safe and effective in the short- and long-term alleviation of IBS associated symptoms as well as improving participant QOL. |
| first_indexed | 2024-04-11T08:42:00Z |
| format | Article |
| id | doaj.art-64e131ad78f4465a95a2f48b16cfcb8a |
| institution | Directory Open Access Journal |
| issn | 1687-630X |
| language | English |
| last_indexed | 2024-04-11T08:42:00Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj.art-64e131ad78f4465a95a2f48b16cfcb8a2022-12-22T04:34:10ZengHindawi LimitedGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/6083896Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical ExperienceHarrison Hamblin0Anoja W. Gunaratne1Annabel Clancy2Denise Pilarinos3Antoinette LeBusque4Marie Vic M. Dawson5Thomas J. Borody6Centre for Digestive DiseasesCentre for Digestive DiseasesCentre for Digestive DiseasesCentre for Digestive DiseasesCentre for Digestive DiseasesCentre for Digestive DiseasesCentre for Digestive DiseasesBackground. The use of faecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) has frequently failed to induce long-term symptomatic improvement. The use of multiple FMT infusions is one proposed mechanism through which the efficacy of FMT can be amplified. Aims. To evaluate the safety and efficacy of a novel six-month FMT treatment protocol in IBS. Methods. Patients diagnosed with IBS confirmed by Rome IV Criteria were recruited for single-centre, single-arm, prospective clinical observational study. Participants received one colonoscopically delivered FMT followed by 36 rectal enemas across a six-month period. Validated abdominal symptoms and Short-Form (SF-36) Quality of Life (QOL) questionnaires were collected at baseline, week-12, week-24, and week-56, respectively. Wilcoxon matched-pairs signed-rank tests were conducted to compare differences in abdominal symptom and SF-36 QOL scores over the follow-up timepoints. Statistical significance was set at 5%. Results. Sixty participants diagnosed with IBS [IBS-constipation (n=27), IBS-diarrhoea (n=18), and IBS-mixed (n=15)] received the six-month FMT treatment. IBS symptom severity reduction was achieved in up to 61% of respondents at week-12, 64% of respondents at week-24, and maintained in up to 75% of respondents at week-52. Long-term reduction in symptom severity was associated with an increase in QOL, achieved in up to 64% of respondents at week-52 when compared to baseline. Adverse events were experienced in 28% of participants, though they were both transient and mild in nature. Conclusions. Six-month sustained FMT appears to be both safe and effective in the short- and long-term alleviation of IBS associated symptoms as well as improving participant QOL.http://dx.doi.org/10.1155/2022/6083896 |
| spellingShingle | Harrison Hamblin Anoja W. Gunaratne Annabel Clancy Denise Pilarinos Antoinette LeBusque Marie Vic M. Dawson Thomas J. Borody Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience Gastroenterology Research and Practice |
| title | Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience |
| title_full | Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience |
| title_fullStr | Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience |
| title_full_unstemmed | Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience |
| title_short | Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience |
| title_sort | pre antibiotic treatment followed by prolonged repeated faecal microbiota transplantation improves symptoms and quality of life in patients with irritable bowel syndrome an observational australian clinical experience |
| url | http://dx.doi.org/10.1155/2022/6083896 |
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