Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice
ObjectiveAuditory steady-state response (ASSR) is a gamma oscillation evoked by periodic auditory stimuli, which is commonly used in clinical electroencephalographic examination to evaluate the neurological functions. Though it has been suggested that auditory cortex is the origin of ASSR, how the l...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnsys.2021.636395/full |
| _version_ | 1819159899123220480 |
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| author | Zijie Li Jinhong Li Shuai Wang Xuejiao Wang Jingyu Chen Ling Qin |
| author_facet | Zijie Li Jinhong Li Shuai Wang Xuejiao Wang Jingyu Chen Ling Qin |
| author_sort | Zijie Li |
| collection | DOAJ |
| description | ObjectiveAuditory steady-state response (ASSR) is a gamma oscillation evoked by periodic auditory stimuli, which is commonly used in clinical electroencephalographic examination to evaluate the neurological functions. Though it has been suggested that auditory cortex is the origin of ASSR, how the laminar architecture of the neocortex contributes to the ASSR recorded from the brain surface remains unclear.MethodsWe used a 16-channel silicon probe to record the local field potential and the single-unit spike activity in the different layers of the auditory cortex of unanesthetized mice. Click-trains with a repetition rate at 40-Hz were present as sound stimuli to evoke ASSR.ResultsWe found that the LFPs of all cortical layers showed a stable ASSR synchronizing to the 40-Hz click stimuli, while the ASSR was strongest in the granular (thalamorecipient) layer. Furthermore, time-frequency analyses also revealed the strongest coherence between the signals recorded from the granular layer and pial surface.ConclusionOur results reveal that the 40-Hz ASSR primarily shows the evoked gamma oscillation of thalamorecipient layers in the neocortex, and that the ASSR may be a biomarker to detect the cognitive deficits associated with impaired thalamo-cortical connection. |
| first_indexed | 2024-12-22T16:47:53Z |
| format | Article |
| id | doaj.art-64e4dfd0d24a4ba783bdd48d766468a8 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-22T16:47:53Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-64e4dfd0d24a4ba783bdd48d766468a82022-12-21T18:19:41ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372021-03-011510.3389/fnsys.2021.636395636395Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake MiceZijie LiJinhong LiShuai WangXuejiao WangJingyu ChenLing QinObjectiveAuditory steady-state response (ASSR) is a gamma oscillation evoked by periodic auditory stimuli, which is commonly used in clinical electroencephalographic examination to evaluate the neurological functions. Though it has been suggested that auditory cortex is the origin of ASSR, how the laminar architecture of the neocortex contributes to the ASSR recorded from the brain surface remains unclear.MethodsWe used a 16-channel silicon probe to record the local field potential and the single-unit spike activity in the different layers of the auditory cortex of unanesthetized mice. Click-trains with a repetition rate at 40-Hz were present as sound stimuli to evoke ASSR.ResultsWe found that the LFPs of all cortical layers showed a stable ASSR synchronizing to the 40-Hz click stimuli, while the ASSR was strongest in the granular (thalamorecipient) layer. Furthermore, time-frequency analyses also revealed the strongest coherence between the signals recorded from the granular layer and pial surface.ConclusionOur results reveal that the 40-Hz ASSR primarily shows the evoked gamma oscillation of thalamorecipient layers in the neocortex, and that the ASSR may be a biomarker to detect the cognitive deficits associated with impaired thalamo-cortical connection.https://www.frontiersin.org/articles/10.3389/fnsys.2021.636395/fullEEGgamma oscillationauditory cortexgranular layerthalamus |
| spellingShingle | Zijie Li Jinhong Li Shuai Wang Xuejiao Wang Jingyu Chen Ling Qin Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice Frontiers in Systems Neuroscience EEG gamma oscillation auditory cortex granular layer thalamus |
| title | Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice |
| title_full | Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice |
| title_fullStr | Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice |
| title_full_unstemmed | Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice |
| title_short | Laminar Profile of Auditory Steady-State Response in the Auditory Cortex of Awake Mice |
| title_sort | laminar profile of auditory steady state response in the auditory cortex of awake mice |
| topic | EEG gamma oscillation auditory cortex granular layer thalamus |
| url | https://www.frontiersin.org/articles/10.3389/fnsys.2021.636395/full |
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