Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling

Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling

Abstract Background GEM (GTP-binding protein overexpressed in skeletal muscle) is one of the atypical small GTPase subfamily members recently identified as a regulator of cell differentiation. Abnormal chondrogenesis coupled with an imbalance in the turnover of cartilaginous matrix formation is high...

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Bibliographic Details
Main Authors: Lu Gan, Zhonghao Deng, Yiran Wei, Hongfang Li, Liang Zhao
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
GEM
Wnt/β-catenin signaling
Chondrogenesis
Osteoarthritis
Online Access:https://doi.org/10.1186/s13018-023-04236-z

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