A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine
The emergence of a novel coronavirus and global pandemic raised the need for the rapid development of new vaccines to reduce the morbidity and mortality associated with Covid-19. Common side effects of these vaccines such as myalgia, arthralgia, nausea, fatigue, and injection site reaction are usual...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-09-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096211043386 |
| _version_ | 1818361138908233728 |
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| author | Natia Murvelashvili MD Alex Tessnow MD |
| author_facet | Natia Murvelashvili MD Alex Tessnow MD |
| author_sort | Natia Murvelashvili MD |
| collection | DOAJ |
| description | The emergence of a novel coronavirus and global pandemic raised the need for the rapid development of new vaccines to reduce the morbidity and mortality associated with Covid-19. Common side effects of these vaccines such as myalgia, arthralgia, nausea, fatigue, and injection site reaction are usually self-resolving. Recognition of other potential adverse effects of these novel vaccines is important due to their rapid and widespread distribution. We report a case of a 51-year-old man admitted to Parkland Memorial Hospital with headache, nausea, vomiting, malaise, and diffuse arthralgias 3 days after he received his second mRNA-1273 SARS-CoV-2 vaccination. He was found to have hyponatremia and a low serum cortisol level. Further workup revealed hypopituitarism with central hypothyroidism, hypogonadism, and a subnormal response to cosyntropin. Magnetic resonance imaging revealed a diffusely enlarged pituitary gland consistent with acute hypophysitis. The patient responded well to glucocorticoid and thyroid hormone supplementation and was discharged after 2 days in the hospital. This is the first reported case of hypopituitarism potentially associated with Covid-19 immunization. |
| first_indexed | 2024-12-13T21:11:56Z |
| format | Article |
| id | doaj.art-64e65546f1fd4a46a284d9ce398f39da |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-13T21:11:56Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-64e65546f1fd4a46a284d9ce398f39da2022-12-21T23:31:20ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962021-09-01910.1177/23247096211043386A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 VaccineNatia Murvelashvili MD0Alex Tessnow MD1The University of Texas Southwestern Medical Center, Dallas, USAThe University of Texas Southwestern Medical Center, Dallas, USAThe emergence of a novel coronavirus and global pandemic raised the need for the rapid development of new vaccines to reduce the morbidity and mortality associated with Covid-19. Common side effects of these vaccines such as myalgia, arthralgia, nausea, fatigue, and injection site reaction are usually self-resolving. Recognition of other potential adverse effects of these novel vaccines is important due to their rapid and widespread distribution. We report a case of a 51-year-old man admitted to Parkland Memorial Hospital with headache, nausea, vomiting, malaise, and diffuse arthralgias 3 days after he received his second mRNA-1273 SARS-CoV-2 vaccination. He was found to have hyponatremia and a low serum cortisol level. Further workup revealed hypopituitarism with central hypothyroidism, hypogonadism, and a subnormal response to cosyntropin. Magnetic resonance imaging revealed a diffusely enlarged pituitary gland consistent with acute hypophysitis. The patient responded well to glucocorticoid and thyroid hormone supplementation and was discharged after 2 days in the hospital. This is the first reported case of hypopituitarism potentially associated with Covid-19 immunization.https://doi.org/10.1177/23247096211043386 |
| spellingShingle | Natia Murvelashvili MD Alex Tessnow MD A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine Journal of Investigative Medicine High Impact Case Reports |
| title | A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine |
| title_full | A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine |
| title_fullStr | A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine |
| title_full_unstemmed | A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine |
| title_short | A Case of Hypophysitis Following Immunization With the mRNA-1273 SARS-CoV-2 Vaccine |
| title_sort | case of hypophysitis following immunization with the mrna 1273 sars cov 2 vaccine |
| url | https://doi.org/10.1177/23247096211043386 |
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