Chromosome Instability, Aging and Brain Diseases
Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes ex...
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MDPI AG
2021-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/1256 |
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| author | Ivan Y. Iourov Yuri B. Yurov Svetlana G. Vorsanova Sergei I. Kutsev |
| author_facet | Ivan Y. Iourov Yuri B. Yurov Svetlana G. Vorsanova Sergei I. Kutsev |
| author_sort | Ivan Y. Iourov |
| collection | DOAJ |
| description | Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and aneuploidy, is likely to contribute to brain aging in health and disease. However, there is no consensus about the occurrence of CIN in the aging brain. As a result, the role of CIN/somatic aneuploidy in normal and pathological brain aging is a matter of debate. Still, taking into account the effects of CIN on cellular homeostasis, the possibility of involvement in brain aging is highly likely. More importantly, the CIN contribution to neuronal cell death may be responsible for neurodegeneration and the aging-related deterioration of the brain. The loss of CIN-affected neurons probably underlies the contradiction between reports addressing ontogenetic changes of karyotypes within the aged brain. In future studies, the combination of single-cell visualization and whole-genome techniques with systems biology methods would certainly define the intrinsic role of CIN in the aging of the normal and diseased brain. |
| first_indexed | 2024-03-10T11:15:10Z |
| format | Article |
| id | doaj.art-64ed0b56dac54a0fa62a5f0532cab294 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:15:10Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-64ed0b56dac54a0fa62a5f0532cab2942023-11-21T20:27:50ZengMDPI AGCells2073-44092021-05-01105125610.3390/cells10051256Chromosome Instability, Aging and Brain DiseasesIvan Y. Iourov0Yuri B. Yurov1Svetlana G. Vorsanova2Sergei I. Kutsev3Yurov’s Laboratory of Molecular Genetics and Cytogenomics of the Brain, Mental Health Research Center, 117152 Moscow, RussiaYurov’s Laboratory of Molecular Genetics and Cytogenomics of the Brain, Mental Health Research Center, 117152 Moscow, RussiaYurov’s Laboratory of Molecular Genetics and Cytogenomics of the Brain, Mental Health Research Center, 117152 Moscow, RussiaResearch Centre for Medical Genetics, 115522 Moscow, RussiaChromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and aneuploidy, is likely to contribute to brain aging in health and disease. However, there is no consensus about the occurrence of CIN in the aging brain. As a result, the role of CIN/somatic aneuploidy in normal and pathological brain aging is a matter of debate. Still, taking into account the effects of CIN on cellular homeostasis, the possibility of involvement in brain aging is highly likely. More importantly, the CIN contribution to neuronal cell death may be responsible for neurodegeneration and the aging-related deterioration of the brain. The loss of CIN-affected neurons probably underlies the contradiction between reports addressing ontogenetic changes of karyotypes within the aged brain. In future studies, the combination of single-cell visualization and whole-genome techniques with systems biology methods would certainly define the intrinsic role of CIN in the aging of the normal and diseased brain.https://www.mdpi.com/2073-4409/10/5/1256aginganeuploidybrain diseaseschromosomechromosome instabilitygenome instability |
| spellingShingle | Ivan Y. Iourov Yuri B. Yurov Svetlana G. Vorsanova Sergei I. Kutsev Chromosome Instability, Aging and Brain Diseases Cells aging aneuploidy brain diseases chromosome chromosome instability genome instability |
| title | Chromosome Instability, Aging and Brain Diseases |
| title_full | Chromosome Instability, Aging and Brain Diseases |
| title_fullStr | Chromosome Instability, Aging and Brain Diseases |
| title_full_unstemmed | Chromosome Instability, Aging and Brain Diseases |
| title_short | Chromosome Instability, Aging and Brain Diseases |
| title_sort | chromosome instability aging and brain diseases |
| topic | aging aneuploidy brain diseases chromosome chromosome instability genome instability |
| url | https://www.mdpi.com/2073-4409/10/5/1256 |
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