Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model
Abstract Membrane-associated mucins (MAMs) are proposed to play critical roles at the ocular surface; however, in vivo evidence has been lacking. Here we investigate these roles by phenotyping of a Muc4 KO mouse. Histochemical analysis for expression of the beta-galactosidase transgene replacing Muc...
Main Authors: | Rafael Martinez-Carrasco, Satyanarayan Rachagani, Surinder K. Batra, Pablo Argüeso, M. Elizabeth Fini |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-40491-0 |
Similar Items
-
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
by: Rachagani Satyanarayana, et al.
Published: (2012-10-01) -
Altered expression of transmembrane mucins, MUC1 and MUC4, in bladder cancer: pathological implications in diagnosis.
by: Sukhwinder Kaur, et al.
Published: (2014-01-01) -
A metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier.
by: Bharathi Govindarajan, et al.
Published: (2012-01-01) -
Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)
by: Prakash G. Kshirsagar, et al.
Published: (2021-12-01) -
Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.
by: Hiroaki Shibahara, et al.
Published: (2014-01-01)