Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

Abstract Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell-mediated tumor regression and memory responses in...

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Bibliographic Details
Main Authors: Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Aditi Patel, Davor Frleta, Jun Zhong, Tomasz Owczarek, Corinne Decker, Lynn Macdonald, Andrew Murphy, Gavin Thurston, Markus Mohrs, Ella Ioffe, Yi-Fen Lu
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04812-3

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