Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.

Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.

Type 2 diabetes (T2D) occurs when there is insufficient insulin release to control blood glucose, due to insulin resistance and impaired β-cell function. The GPR39 receptor is expressed in metabolic tissues including pancreatic β-cells and has been proposed as a T2D target. Specifically, GPR39 agoni...

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Bibliographic Details
Main Authors: Ola Fjellström, Niklas Larsson, Shin-Ichiro Yasuda, Takuma Tsuchida, Takahiro Oguma, Anna Marley, Charlotte Wennberg-Huldt, Daniel Hovdal, Hajime Fukuda, Yukimi Yoneyama, Kazuyo Sasaki, Anders Johansson, Sara Lundqvist, Johan Brengdahl, Richard J Isaacs, Daniel Brown, Stefan Geschwindner, Lambertus Benthem, Claire Priest, Andrew Turnbull
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4697807?pdf=render

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