Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy
We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiograph...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2020-10-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/510096 |
| _version_ | 1818340978599133184 |
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| author | Shenthol Sasankan Lorraine Rebuck Gloria Darrah Moises Harari Turquie Ian Rabinowitz |
| author_facet | Shenthol Sasankan Lorraine Rebuck Gloria Darrah Moises Harari Turquie Ian Rabinowitz |
| author_sort | Shenthol Sasankan |
| collection | DOAJ |
| description | We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer. |
| first_indexed | 2024-12-13T15:51:29Z |
| format | Article |
| id | doaj.art-64f08a7e689d47d2902d3944f3acc21e |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-13T15:51:29Z |
| publishDate | 2020-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-64f08a7e689d47d2902d3944f3acc21e2022-12-21T23:39:28ZengKarger PublishersCase Reports in Oncology1662-65752020-10-011331239124310.1159/000510096510096Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted TherapyShenthol SasankanLorraine RebuckGloria DarrahMoises Harari TurquieIan RabinowitzWe report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer.https://www.karger.com/Article/FullText/510096braf mutationcancer biologygastrointestinal oncologypancreatic cancertargeted therapy |
| spellingShingle | Shenthol Sasankan Lorraine Rebuck Gloria Darrah Moises Harari Turquie Ian Rabinowitz Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy Case Reports in Oncology braf mutation cancer biology gastrointestinal oncology pancreatic cancer targeted therapy |
| title | Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy |
| title_full | Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy |
| title_fullStr | Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy |
| title_full_unstemmed | Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy |
| title_short | Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy |
| title_sort | metastatic pancreatic cancer with braf and p53 mutations case report of therapeutic response to doublet targeted therapy |
| topic | braf mutation cancer biology gastrointestinal oncology pancreatic cancer targeted therapy |
| url | https://www.karger.com/Article/FullText/510096 |
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