Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease
A thinning of intraretinal layers has been previously described in Parkinson's disease (PD) patients compared to healthy controls (HCs). Few studies evaluated the possible correlation between retinal thickness and retinal microvascularization. Thus, here we assessed the thickness of retinal lay...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.533375/full |
| _version_ | 1819266353986535424 |
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| author | Cristina Rascunà Andrea Russo Claudio Terravecchia Niccolò Castellino Teresio Avitabile Vincenza Bonfiglio Matteo Fallico Clara Grazia Chisari Calogero Edoardo Cicero Marco Grillo Antonio Longo Antonina Luca Giovanni Mostile Mario Zappia Michele Reibaldi Alessandra Nicoletti |
| author_facet | Cristina Rascunà Andrea Russo Claudio Terravecchia Niccolò Castellino Teresio Avitabile Vincenza Bonfiglio Matteo Fallico Clara Grazia Chisari Calogero Edoardo Cicero Marco Grillo Antonio Longo Antonina Luca Giovanni Mostile Mario Zappia Michele Reibaldi Alessandra Nicoletti |
| author_sort | Cristina Rascunà |
| collection | DOAJ |
| description | A thinning of intraretinal layers has been previously described in Parkinson's disease (PD) patients compared to healthy controls (HCs). Few studies evaluated the possible correlation between retinal thickness and retinal microvascularization. Thus, here we assessed the thickness of retinal layers and microvascular pattern in early PD patients and HCs, using, respectively, spectral-domain optical coherence tomography (SD-OCT) and SD-OCT-angiography (SD-OCT-A), and more interestingly, we evaluated a possible correlation between retinal thickness and microvascular pattern. Patients fulfilling criteria for clinically established/clinically probable PD and HCs were enrolled. Exclusion criteria were any ocular, retinal, and systemic disease impairing the visual system. Retinal vascularization was analyzed using SD-OCT-A, and retinal layer thickness was assessed using SD-OCT. Forty-one eyes from 21 PD patients and 33 eyes from 17 HCs were evaluated. Peripapillary retinal nerve fiber layer (RNFL) and macular RNFL, ganglionic cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL), resulted to be thinner in PD compared to HCs. Among PD patients, a positive correlation between RNFL, GCL, and IPL thickness and microvascular density was found in the foveal region, also adjusting by age, sex, and, especially, hypertension. Such findings were already present in the early stage of disease and were irrespective of dopaminergic treatment. Thus, the retina might be considered a biomarker of PD and could be a useful instrument for onset and disease progression. |
| first_indexed | 2024-12-23T20:59:56Z |
| format | Article |
| id | doaj.art-64f0f69d310e4534ac18f7cad4d22a68 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T20:59:56Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-64f0f69d310e4534ac18f7cad4d22a682022-12-21T17:31:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-10-011110.3389/fneur.2020.533375533375Retinal Thickness and Microvascular Pattern in Early Parkinson's DiseaseCristina Rascunà0Andrea Russo1Claudio Terravecchia2Niccolò Castellino3Teresio Avitabile4Vincenza Bonfiglio5Matteo Fallico6Clara Grazia Chisari7Calogero Edoardo Cicero8Marco Grillo9Antonio Longo10Antonina Luca11Giovanni Mostile12Mario Zappia13Michele Reibaldi14Alessandra Nicoletti15Section of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalyDepartment of Ophthalmology, University of Catania, Catania, ItalySection of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, ItalyA thinning of intraretinal layers has been previously described in Parkinson's disease (PD) patients compared to healthy controls (HCs). Few studies evaluated the possible correlation between retinal thickness and retinal microvascularization. Thus, here we assessed the thickness of retinal layers and microvascular pattern in early PD patients and HCs, using, respectively, spectral-domain optical coherence tomography (SD-OCT) and SD-OCT-angiography (SD-OCT-A), and more interestingly, we evaluated a possible correlation between retinal thickness and microvascular pattern. Patients fulfilling criteria for clinically established/clinically probable PD and HCs were enrolled. Exclusion criteria were any ocular, retinal, and systemic disease impairing the visual system. Retinal vascularization was analyzed using SD-OCT-A, and retinal layer thickness was assessed using SD-OCT. Forty-one eyes from 21 PD patients and 33 eyes from 17 HCs were evaluated. Peripapillary retinal nerve fiber layer (RNFL) and macular RNFL, ganglionic cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL), resulted to be thinner in PD compared to HCs. Among PD patients, a positive correlation between RNFL, GCL, and IPL thickness and microvascular density was found in the foveal region, also adjusting by age, sex, and, especially, hypertension. Such findings were already present in the early stage of disease and were irrespective of dopaminergic treatment. Thus, the retina might be considered a biomarker of PD and could be a useful instrument for onset and disease progression.https://www.frontiersin.org/article/10.3389/fneur.2020.533375/fullparkinson's diseaseretinavascularizationoptical coherence tomographyoptical coherence tomography angiography |
| spellingShingle | Cristina Rascunà Andrea Russo Claudio Terravecchia Niccolò Castellino Teresio Avitabile Vincenza Bonfiglio Matteo Fallico Clara Grazia Chisari Calogero Edoardo Cicero Marco Grillo Antonio Longo Antonina Luca Giovanni Mostile Mario Zappia Michele Reibaldi Alessandra Nicoletti Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease Frontiers in Neurology parkinson's disease retina vascularization optical coherence tomography optical coherence tomography angiography |
| title | Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease |
| title_full | Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease |
| title_fullStr | Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease |
| title_full_unstemmed | Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease |
| title_short | Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease |
| title_sort | retinal thickness and microvascular pattern in early parkinson s disease |
| topic | parkinson's disease retina vascularization optical coherence tomography optical coherence tomography angiography |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.533375/full |
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