Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline

Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline

Background/Aims: Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic fibrosis (CF). Degradation of ceramide concentrations in lungs of CF patients employing the functional acid sphingomyelinase inhibitor amitriptyline revealed a...

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Bibliographic Details
Main Authors: Constantin Adams, Vanya Icheva, Caroline Deppisch, Josefine Lauer, Gloria Herrmann, Ute Graepler-Mainka, Susanne Heyder, Erich Gulbins, Joachim Riethmueller
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cystic Fibrosis
Amitriptyline
Ceramide
CFTR
Online Access:http://www.karger.com/Article/FullText/445648

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