A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy
Hypercalcemia due to primary hyperparathyroidism (PHPT) is uncommon in children. PHPT is typically caused by a single parathyroid adenoma. Ectopic parathyroid adenomas account for 6%–16% of all parathyroid adenomas and are rare in children but should be considered in cases that present with hypercal...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2020-07-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
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| Online Access: | http://e-apem.org/upload/pdf/apem-1938172-086.pdf |
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| author | Youngseok Seo Kyungchul Song Han Saem Choi Junghwan Suh Ahreum Kwon Hyun Wook Chae Ho-Seong Kim |
| author_facet | Youngseok Seo Kyungchul Song Han Saem Choi Junghwan Suh Ahreum Kwon Hyun Wook Chae Ho-Seong Kim |
| author_sort | Youngseok Seo |
| collection | DOAJ |
| description | Hypercalcemia due to primary hyperparathyroidism (PHPT) is uncommon in children. PHPT is typically caused by a single parathyroid adenoma. Ectopic parathyroid adenomas account for 6%–16% of all parathyroid adenomas and are rare in children but should be considered in cases that present with hypercalcemia. We report the case of a 15-year-old boy with PHPT due to an intrathymic ectopic parathyroid adenoma. Neck ultrasonography and Tc-99m-sestamibi (MIBI) scanning with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed ectopic parathyroid adenoma in the thymus. Video-assisted thoracoscopic surgery was performed to remove the ectopic parathyroid adenoma. Pathology showed intrathymic ectopic parathyroid adenoma. After surgery, the patient’s serum calcium level immediately normalized. Intact parathyroid hormone (iPTH) and alkaline phosphatase levels returned to normal ranges within 3 months. Delayed diagnosis of PHPT can cause end-organ damage; a timely diagnosis is especially critical to preserve bone and renal function. If ectopic parathyroid adenomas are well localized in preoperative imaging evaluation and intraoperative iPTH level decreases after resection, ectopic parathyroidectomy without bilateral neck exploration may be performed to avoid unnecessary morbidity. |
| first_indexed | 2024-12-12T06:15:42Z |
| format | Article |
| id | doaj.art-64f30241a214454fa7b2ffb3a22425e2 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-12T06:15:42Z |
| publishDate | 2020-07-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-64f30241a214454fa7b2ffb3a22425e22022-12-22T00:35:02ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922020-07-0125318719110.6065/apem.1938172.086829A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boyYoungseok Seo0Kyungchul Song1Han Saem Choi2Junghwan Suh3Ahreum Kwon4Hyun Wook Chae5Ho-Seong Kim Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, KoreaHypercalcemia due to primary hyperparathyroidism (PHPT) is uncommon in children. PHPT is typically caused by a single parathyroid adenoma. Ectopic parathyroid adenomas account for 6%–16% of all parathyroid adenomas and are rare in children but should be considered in cases that present with hypercalcemia. We report the case of a 15-year-old boy with PHPT due to an intrathymic ectopic parathyroid adenoma. Neck ultrasonography and Tc-99m-sestamibi (MIBI) scanning with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed ectopic parathyroid adenoma in the thymus. Video-assisted thoracoscopic surgery was performed to remove the ectopic parathyroid adenoma. Pathology showed intrathymic ectopic parathyroid adenoma. After surgery, the patient’s serum calcium level immediately normalized. Intact parathyroid hormone (iPTH) and alkaline phosphatase levels returned to normal ranges within 3 months. Delayed diagnosis of PHPT can cause end-organ damage; a timely diagnosis is especially critical to preserve bone and renal function. If ectopic parathyroid adenomas are well localized in preoperative imaging evaluation and intraoperative iPTH level decreases after resection, ectopic parathyroidectomy without bilateral neck exploration may be performed to avoid unnecessary morbidity.http://e-apem.org/upload/pdf/apem-1938172-086.pdfprimary hyperparathyroidismhypercalcemiaectopic parathyroid glandparathyroid adenomachild |
| spellingShingle | Youngseok Seo Kyungchul Song Han Saem Choi Junghwan Suh Ahreum Kwon Hyun Wook Chae Ho-Seong Kim A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy Annals of Pediatric Endocrinology & Metabolism primary hyperparathyroidism hypercalcemia ectopic parathyroid gland parathyroid adenoma child |
| title | A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy |
| title_full | A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy |
| title_fullStr | A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy |
| title_full_unstemmed | A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy |
| title_short | A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy |
| title_sort | case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15 year old boy |
| topic | primary hyperparathyroidism hypercalcemia ectopic parathyroid gland parathyroid adenoma child |
| url | http://e-apem.org/upload/pdf/apem-1938172-086.pdf |
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