The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer
Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic condition...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.714795/full |
| _version_ | 1818690885285576704 |
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| author | Soudeh Ghafouri-Fard Amin Aghabalazade Hamed Shoorei Jamal Majidpoor Mohammad Taheri Majid Mokhtari |
| author_facet | Soudeh Ghafouri-Fard Amin Aghabalazade Hamed Shoorei Jamal Majidpoor Mohammad Taheri Majid Mokhtari |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Apoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer. |
| first_indexed | 2024-12-17T12:33:06Z |
| format | Article |
| id | doaj.art-64f4b375b1f94ecaa03cad560bc206ca |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T12:33:06Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-64f4b375b1f94ecaa03cad560bc206ca2022-12-21T21:48:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.714795714795The Impact of lncRNAs and miRNAs on Apoptosis in Lung CancerSoudeh Ghafouri-Fard0Amin Aghabalazade1Hamed Shoorei2Jamal Majidpoor3Mohammad Taheri4Majid Mokhtari5Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacology, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Anatomical Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, IranSkull Base Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranCritical Care Quality improvement Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranApoptosis is a coordinated cellular process that occurs in several physiological situations. Dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms. Lung cancer is among neoplastic conditions in which the role of non-coding RNAs in the regulation of apoptosis has been investigated. Non-coding RNAs that regulate apoptosis in lung cancer have functional interactions with PI3K/Akt, PTEN, GSK-3β, NF-κB, Bcl-2, Bax, p53, mTOR and other important cancer-related pathways. Globally, over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis of patients, while apoptosis-promoting ones have the opposite effect. In the current paper, we describe the impact of lncRNAs and miRNAs on cell apoptosis in lung cancer.https://www.frontiersin.org/articles/10.3389/fonc.2021.714795/fulllncRNAmiRNAapoptosislung cancerexpression |
| spellingShingle | Soudeh Ghafouri-Fard Amin Aghabalazade Hamed Shoorei Jamal Majidpoor Mohammad Taheri Majid Mokhtari The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer Frontiers in Oncology lncRNA miRNA apoptosis lung cancer expression |
| title | The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer |
| title_full | The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer |
| title_fullStr | The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer |
| title_full_unstemmed | The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer |
| title_short | The Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer |
| title_sort | impact of lncrnas and mirnas on apoptosis in lung cancer |
| topic | lncRNA miRNA apoptosis lung cancer expression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.714795/full |
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