Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon
Abstract Background Macroparasites, such as ticks, lice, and helminths, are a concern in livestock and aquaculture production, and can be controlled by genetic improvement of the host population. Genetic improvement should aim at reducing the rate at which parasites spread across the farmed populati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
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BMC
2018-10-01
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| Series: | Genetics Selection Evolution |
| Online Access: | http://link.springer.com/article/10.1186/s12711-018-0418-6 |
| _version_ | 1818218939025457152 |
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| author | Kasper Janssen Hans Komen Helmut W. Saatkamp Mart C. M. de Jong Piter Bijma |
| author_facet | Kasper Janssen Hans Komen Helmut W. Saatkamp Mart C. M. de Jong Piter Bijma |
| author_sort | Kasper Janssen |
| collection | DOAJ |
| description | Abstract Background Macroparasites, such as ticks, lice, and helminths, are a concern in livestock and aquaculture production, and can be controlled by genetic improvement of the host population. Genetic improvement should aim at reducing the rate at which parasites spread across the farmed population. This rate is determined by the basic reproduction ratio, i.e. $${\text{R}}_{0}$$ R0 , which is the appropriate breeding goal trait. This study aims at providing a method to derive the economic value of $${\text{R}}_{0}$$ R0 . Methods Costs of a disease are the sum of production losses and expenditures on disease control. Genetic improvement of $${\text{R}}_{0}$$ R0 lowers the loss-expenditure frontier. Its economic effect depends on whether the management strategy is optimized or not. The economic value may be derived either from the reduction in losses with constant expenditures or from the reduction in expenditures with constant losses. Results When $${\text{R}}_{0}$$ R0 ≤ 1, the economic value of a further reduction is zero because there is no risk of a major epidemic. When $${\text{R}}_{0}$$ R0 > 1 and management is optimized, the economic value increases with decreasing values of $${\text{R}}_{0}$$ R0 , because both the mean number of parasites per host and frequency of treatments decrease at an increasing rate when $${\text{R}}_{0}$$ R0 decreases. When $${\text{R}}_{0}$$ R0 > 1 and management is not optimized, the economic value depends on whether genetic improvement is used for reducing expenditures or losses. For sea lice in salmon, the economic value depends on a reduction in expenditures with constant losses, and is estimated to be 0.065€/unit $${\text{R}}_{0}$$ R0 /kg production. Discussion Response to selection for measures of disease prevalence cannot be predicted from quantitative genetic theory alone. Moreover, many studies fail to address the issue of whether genetic improvement results in reduced losses or expenditures. Using $${\text{R}}_{0}$$ R0 as the breeding goal trait, weighed by its appropriate economic value, avoids these issues. Conclusion When management is optimized, the economic value increases with decreasing values of $${\text{R}}_{0}$$ R0 (until the threshold of $${\text{R}}_{0} = 1$$ R0=1 , where it drops to zero). When management is not optimized, the economic value depends on whether genetic improvement is used for reduced expenditures or production losses. For sea lice in salmon, the economic value is estimated to be 0.065 €/unit $${\text{R}}_{0}$$ R0 /kg production. |
| first_indexed | 2024-12-12T07:31:43Z |
| format | Article |
| id | doaj.art-64f582c2e78d4b58aeed81a4b2f9d7ff |
| institution | Directory Open Access Journal |
| issn | 1297-9686 |
| language | deu |
| last_indexed | 2024-12-12T07:31:43Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Genetics Selection Evolution |
| spelling | doaj.art-64f582c2e78d4b58aeed81a4b2f9d7ff2022-12-22T00:33:01ZdeuBMCGenetics Selection Evolution1297-96862018-10-0150111210.1186/s12711-018-0418-6Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmonKasper Janssen0Hans Komen1Helmut W. Saatkamp2Mart C. M. de Jong3Piter Bijma4Animal Breeding and Genomics, Wageningen University and ResearchAnimal Breeding and Genomics, Wageningen University and ResearchBusiness Economics, Wageningen University and ResearchQuantitative Veterinary Epidemiology, Wageningen University and ResearchAnimal Breeding and Genomics, Wageningen University and ResearchAbstract Background Macroparasites, such as ticks, lice, and helminths, are a concern in livestock and aquaculture production, and can be controlled by genetic improvement of the host population. Genetic improvement should aim at reducing the rate at which parasites spread across the farmed population. This rate is determined by the basic reproduction ratio, i.e. $${\text{R}}_{0}$$ R0 , which is the appropriate breeding goal trait. This study aims at providing a method to derive the economic value of $${\text{R}}_{0}$$ R0 . Methods Costs of a disease are the sum of production losses and expenditures on disease control. Genetic improvement of $${\text{R}}_{0}$$ R0 lowers the loss-expenditure frontier. Its economic effect depends on whether the management strategy is optimized or not. The economic value may be derived either from the reduction in losses with constant expenditures or from the reduction in expenditures with constant losses. Results When $${\text{R}}_{0}$$ R0 ≤ 1, the economic value of a further reduction is zero because there is no risk of a major epidemic. When $${\text{R}}_{0}$$ R0 > 1 and management is optimized, the economic value increases with decreasing values of $${\text{R}}_{0}$$ R0 , because both the mean number of parasites per host and frequency of treatments decrease at an increasing rate when $${\text{R}}_{0}$$ R0 decreases. When $${\text{R}}_{0}$$ R0 > 1 and management is not optimized, the economic value depends on whether genetic improvement is used for reducing expenditures or losses. For sea lice in salmon, the economic value depends on a reduction in expenditures with constant losses, and is estimated to be 0.065€/unit $${\text{R}}_{0}$$ R0 /kg production. Discussion Response to selection for measures of disease prevalence cannot be predicted from quantitative genetic theory alone. Moreover, many studies fail to address the issue of whether genetic improvement results in reduced losses or expenditures. Using $${\text{R}}_{0}$$ R0 as the breeding goal trait, weighed by its appropriate economic value, avoids these issues. Conclusion When management is optimized, the economic value increases with decreasing values of $${\text{R}}_{0}$$ R0 (until the threshold of $${\text{R}}_{0} = 1$$ R0=1 , where it drops to zero). When management is not optimized, the economic value depends on whether genetic improvement is used for reduced expenditures or production losses. For sea lice in salmon, the economic value is estimated to be 0.065 €/unit $${\text{R}}_{0}$$ R0 /kg production.http://link.springer.com/article/10.1186/s12711-018-0418-6 |
| spellingShingle | Kasper Janssen Hans Komen Helmut W. Saatkamp Mart C. M. de Jong Piter Bijma Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon Genetics Selection Evolution |
| title | Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon |
| title_full | Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon |
| title_fullStr | Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon |
| title_full_unstemmed | Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon |
| title_short | Derivation of the economic value of R0 for macroparasitic diseases and application to sea lice in salmon |
| title_sort | derivation of the economic value of r0 for macroparasitic diseases and application to sea lice in salmon |
| url | http://link.springer.com/article/10.1186/s12711-018-0418-6 |
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